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PART 4 Anatomy and Physiology of Animals
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LYSIS T (thymic) lymphocyte scout Antigen antibody reaction Transforms
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Fig 172 Antibodies and macrophages attack foreign antigens
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entire invading cells and their foreign antigens by means of phagocytosis (cell eating) Hence, by two major processes, antigen antibody reactions and phagocytosis, a state of immunity from disease is usually accomplished within the human body
4, Order
CHAPTER 17 Immune/Lymphatic Systems
The Major Lymphatic Organs
So far, we have mainly been focusing upon the lymphatic vessels and the defensive reactions of the immune system But, remember that the lymphatic system consists of a collection of lymphatic organs, as well as lymphatic vessels
THE LYMPH NODES
The most widespread lymphatic organs are the lymph nodes (NOADS) The lymph nodes are a group of small, bean-like organs scattered in clusters in various parts of the body (Figure 173) A erent (AF-fer-ent) lymphatic vessels carry (fer) dirty lymph towards (af-) the lymph nodes E erent (EE-fer-ent) lymphatic vessels carry clean lymph away from (ef-) them
THE THYMUS GLAND
A most unusual lymphatic organ is the thymus (THIGH-mus) gland The word, thymus, comes from the Ancient Greek for warty outgrowth, re ecting the bumpy appearance of this endocrine gland The thymus is a thin, at gland lying just deep to the sternum (STER-num) or breastplate This gland consists of two bumpy-looking lobes The thymus gland secretes the hormone, thymosin (thigh-MOH-sin), which stimulates the activity of the lymphocytes and other parts of the body s immune system It also produces thymic (THIGH-mik) lymphocytes (introduced as T-cells or T-lymphocytes, earlier) The thymus gland is most prominent in young humans and other mammals (In lambs, it is called the throat sweetbread, because it is often eaten as sweet-tasting meat) It reaches its maximum size at puberty, then progressively decreases in size In most adults, the thymus is completely gone, having been replaced by fatty connective tissue The thymus is thought to play an important role in the development of immune competence in youngsters a growing ability to ward o various diseases The disappearance of the thymus in adults may be related to the gradual decline of immune competence seen in older persons, thereby making them more susceptible to cancer and pneumonia
PART 4 Anatomy and Physiology of Animals
Afferent: dirty lymph vessels LYMPH NODE Efferent: clean lymph vessels THYMUS GLAND
SPLEEN
RED BONE MARROW
Fig 173 Some major lymphatic organs in humans
RED BONE MARROW
The red bone marrow found within spongy bone ( 13) is a third important type of lymphatic organ Besides its role in hematopoiesis (blood cell formation), the red bone marrow is a source of B-lymphocytes As you may recall, the B-lymphocytes di erentiate into plasma cells when they are chemically signaled by the T-lymphocytes that a foreign invader (antigen) is present And these plasma cells, in turn, produce antibodies
SPLEEN
In humans, the spleen is a dark red organ attached to the left side of the stomach It looks somewhat like a thick, crescent-shaped-roll (croissant), and it rather feels like one, being soft and spongy to the touch Besides hematopoiesis, the spleen (like the red bone marrow) is involved in the recycling and destruction of old, beaten-up erythrocytes It also stores blood and contains a lot of lymphatic tissue The spleen is rich in lymphocytes, plasma cells, and
CHAPTER 17 Immune/Lymphatic Systems
wandering macrophages (mostly derived from monocytes) It is therefore an important helper in phagocytosis of foreign invaders, such as bacteria, as well as devouring fragments of broken erythrocytes
The Tonsils: Little Almonds In the Back of Our Throat
In addition to full-blown lymphatic organs, there are smaller masses of lymphatic tissue scattered here and there around the body Prominent among these are the tonsils (TAHN-sils) The tonsils are literally little almonds (tonsils) oval, somewhat almond-shaped clusters of lymphatic tissue lying in the back of the throat (Figure 174)
Pharyngeal tonsil (adenoids) Palatine tonsil Palatine tonsil Lingual tonsil (A) Real almonds
Fig 174 The tonsils: Little almonds tucked away in our throats (A) Frontal view (B) Side view
Pharyngeal tonsil
Lingual tonsil (B)
In humans, there are ve tonsils The pharyngeal (fah-RIN-jee-al) tonsil is the single uppermost mass, located in the portion of the pharynx (FAIR-inks) or throat just behind the nose The pharyngeal tonsil is also called the adenoids (AD-uh-noyds), because it is rather big and gland (aden) like (-oid) The two palatine (PAL-ah-tyn) tonsils, as their name indicates, are a pair of tonsils lying on either side of the throat, just below the palate (PAL-aht) or roof of the mouth Finally, there is a pair of lingual (LING-gwal) tonsils, attached way back at the base of the tongue (lingu)
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