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Peptide bond RIBOSOME mRNA A POLYPEPTIDE (small protein fragment)
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tRNA Attached amino acids
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Fig 54 Some basic steps in protein synthesis
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DNA codons exposed
CHAPTER 5 Cells: The Little Chambers
mRNA codons is translated or changed into the amino acid language of a certain protein The tRNA molecules match their bases up against complementary bases of the mRNA molecule The amino acids attached at the other end of the tRNAs link together via peptide (PEP-tide) bonds The end result is a nished protein or polypeptide (PAH-lee-pep-tide) a combination of many (poly-) amino acids connected by peptide bonds in a coded order Each completed protein (polypeptide) detaches from a ribosome and begins to perform its special function within the cell
Abnormal Organelles: Biological Disorder in Cells
Our earlier discussion of various normal organelles suggested the presence of Biological Order within cells In general, such an order or pattern supports and maintains the health and survival of the cell What happens, however, when a cell organelle becomes abnormal or damaged Certainly, one would expect to see some type of associated illness or cellular problem Consider, for example, the condition called cell autolysis (aw-TAH-luh-sis) or self breakdown of a cell When a particular cell is dying, dozens of its lysosomes may rupture simultaneously This rupturing releases thousands of stored digestive enzyme molecules When such a huge number of these powerfully dissolving enzymes are present at the same time, they break down the whole cell Cell autolysis thereby often serves to remove dead or dying cells from otherwise healthy body tissue Unnecessary (and perhaps disruptive) build-up of extra dead cells is prevented
1, Disorder
Transport through the Cell Membrane
The cell organelles, whether normal or abnormal, require transport systems across the cell membrane to keep themselves functioning Transport systems within the cell, like highway systems in a city, provide a nearly constant movement of particles or objects, some of them moving in, others moving out Transport systems are needed because the plasma membrane is a selectively permeable (PER-me-ah-bl) membrane By selectively permeable, it is
PART 2 Universal Building Blocks of Life
meant that certain types of particles are able to permeate (PER-me-ate) or pass through the cell membrane, while others are not able to pass There are two basic types of transport systems that move particles across the cell membrane: passive transport systems versus active transport systems Passive transport systems are passive in the sense that they do not require any active input of ATP energy to function Active transport systems, in direct opposite, are those systems in which free energy from splitting ATP energy is needed
PASSIVE TRANSPORT SYSTEMS
There are three common types of passive transport systems serving cells These are simple di usion, osmosis (ahs-MOH-sis), and facilitated (fahSIH-lih-tay-ted) di usion Di usion is literally a process of scattering (diffus) The scattering process of di usion arises from the fact that all particles are constantly moving in random directions During simple di usion, particles move by chance from a region where their concentration is high, to a region where their concentration is low Oxygen (O2) molecules, for instance, tend to have a much higher concentration (crowding together) in the uid outside of most cells, compared to their concentration within the cell Why does this make sense The reason is that oxygen molecules are being constantly used within cells for their aerobic metabolism Thus, the intracellular (IN-trah-sell-yew-lar) uid present within (intra-) the cell, generally has a low O2 concentration But the extracellular (EKS-trah-sell-yew-lar) uid outside (extra-) the cell typically has a high O2 concentration Hence, there is a net (overall) simple di usion of oxygen molecules from the extracellular uid, across the plasma membrane, and into the intracellular uid [Study suggestion: Open a bottle of perfume Place it onto a table in a quiet room After half an hour or so, return to the room Do you smell the perfume in the far corners of the room Explain this observation] Closely related to simple di usion is osmosis Osmosis is a condition of thrusting (osm-) Speci cally, osmosis is the simple di usion of water (H2O) molecules only, from a region where the water concentration is high, to a region where the water concentration is low Think about a row of small green plants In dry soil, their leaves and stems soon wither But when the soil is freshly watered, the leaves and stems expand and sti en Osmosis of millions of H2O molecules occurs from the moistened soil (having a high water concentration) into the cells of the green plants (which have a lower water concentration) The thrusting origin of the word osmosis therefore re ects
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