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Neuromuscular Disorders: Breaking the Connections
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We have now outlined some of the major aspects of the nervous and muscular systems Primarily, this outline has involved basic features of their normal anatomy and physiology To a large degree, these two systems are functionally linked due to the extremely high degree of Biological Order found in the connections between them Hence, neuromuscular disorders,
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CHAPTER 14 Neuromuscular Connection
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Action potentials (visual impulses) Optic nerve Retina Real person viewed VISUAL ASSOCIATION AREA (integrates visual sensory information)
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Meaningful associations PRIMARY VISUAL AREA
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Fig 1413 The primary visual and visual association areas
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and the disease/injury states often associated with them, frequently result from the breaking or disruption of the normal connections between muscles and nerves
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PARALYSIS AND DENERVATION ATROPHY
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Consider what happens, for instance, when part of the major motor pathway descending to the skeletal muscles is transected (tran-SEK-ted) or cut (sect) all the way through (trans-) When the motor nerve bers from the precentral gyrus (primary motor area) are transected (cut all the way through), say, from a terrible car accident, then either partial or full paralysis (puhRAL-uh-sis) of the body occurs Paralysis is literally a state of disablement, an inability to move The axons of the motor neurons leading from the motor areas of the cerebral cortex are unable to complete their nal connection with the neuromuscular junction (motor end plate) As a result, there is either a full or total paralysis of the skeletal muscles being supplied [Study suggestion: If the main motor pathway leading down from the left precentral gyrus is transected, then many of the skeletal muscles on which side of the body will be paralyzed Why ] Troph (TROHF) is a root that means nourishment But troph means nourishment in its broadest sense, including stimulation The skeletal
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PART 4 Anatomy and Physiology of Animals
muscle bers, then, receive nourishment by the motor nerve bers coming down to the neuromuscular junction, because they are stimulated to contract by them In technical terms, we say that the skeletal muscle bers are innervated (IN-ur-vayt-ed) or have nerve (nerv) endings put into (in-) them This situation of innervation (in-er-VAY-shun) essentially occurs at the neuromuscular junction The skeletal muscle bers are therefore innervated at the neuromuscular junction and receive nourishment or stimulation (troph) from them Denervation (dee-ner-VAY-shun) is the process of (-tion) taking nerves (nerv) away from (de-) muscle bers If some part of the motor nerve pathway undergoes transection, then the skeletal muscle bers ultimately being served by the pathway will su er denervation They will also undergo a type of atrophy (AT-ruh-fee) a condition (-y) without (a-) nourishment (troph) or stimulation The complete phrase is denervation atrophy, which means the wasting away and degeneration of skeletal muscle bers that have been deprived of their normal stimulation or nourishment by nerve endings The denervated (DEH-ner-vayt-ed) muscles become accid (FLAH-sid) or abby and almost useless
ANESTHESIA LOSS OF FEELING OR SENSATION
When the sensory nerve bers leading from sensory receptors in muscles, joints, skin, or elsewhere are transected, then anesthesia (an-es-THEEzhuh) often results Anesthesia is a condition (-ia) without (an-) feeling or sensation (esthes) If, for instance, the sensory nerves leading from most of the receptors in your big toe are completely transected, then the big toe is pretty much numb, re ecting a condition of anesthesia [Study suggestion: Assume that the main sensory nerve pathway ascending from your right big toe is completely transected Going back and reviewing past gures in this chapter, which speci c gyrus area receiving big toe sensations would be deprived On which side of the body midline would it most likely be located ]
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Quiz
Refer to the text in this chapter if necessary A good score is at least 8 correct answers out of these 10 questions The answers are listed in the back of this book
CHAPTER 14 Neuromuscular Connection
1 The muscular system of humans: (a) Involves mainly the muscles in the walls of the heart (b) Is chie y composed of over 600 individual skeletal muscle organs (c) Focuses upon about 700 pairs of skeletal muscle tissues (d) Bears no relationship to bones or tendons The masseter muscle in the jaw is named for the characteristic of: (a) Muscle shape (b) Body location (c) Major body action (d) Number of muscle heads In bending and straightening of the lower leg, the knee joint serves as a: (a) Fulcrum (b) Lever (c) Resistance (d) Pulling force When the biceps brachii contracts, it exes (bends) the lower arm at the elbow The insertion of the biceps brachii must therefore be at the: (a) Shoulder (b) Wrist (c) Fingers (d) Elbow Epimysium represents: (a) A special type of joint (b) A type of fascia located upon an entire skeletal muscle (c) Fascia located around a bundle of muscle bers (d) Striated muscle bers The striations of an individual skeletal muscle ber are chie y due to: (a) A stack of light I bands within the myo brils (b) Several groups of muscle cell nuclei closely adjacent to one another (c) A stack of dark A bands within the myo brils (d) Complete lack of any signi cant organelle banding patterns The thin myo laments primarily consist of the protein _____ (a) Actin (b) Myosin (c) Z-line (d) Cross-bridge substance
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