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PART 4 Anatomy and Physiology of Animals
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NEURON AXON NEURON AXON Vesicles Skeletal muscle fiber Neurotransmitter molecules NEURON (A) NEUROMUSCULAR JUNCTION (B) SYNAPSE Hormone molecules Bloodstream
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(C) EXOCRINE GLANDS
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(D) ENDOCRINE GLANDS
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Hormone target cells
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Fig 151 Two ways for cells to communicate: Neurotransmitters versus secretions
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vertebrates In fact, it is sometimes very hard to separate the nervous and endocrine systems at all! In these cases, we use the term neuroendocrine (NUR-oh-en-doh-krin) system to describe them The neuroendocrine system is an organ system that contains parts of the nervous system, as well as parts of the endocrine gland system Thus, communication can occur via release of neurotransmitters (the nervous component), and also via secretion of particular hormones into the bloodstream (the endocrine component) We will now describe some speci c examples
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THE HYPOTHALAMUS PITUITARY CONNECTION
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14 described the hypothalamus as an area deep within the cerebrum that contains a number of control centers (such as the temperature control center) that are vitally important for maintaining various aspects of home-
CHAPTER 15 Glands and Messengers
ostasis Located just below the hypothalamus is a narrow, funnel-shaped pituitary (pih-TWO-eh-tear-ee) stalk This hollow stalk is attached to the top of the pituitary body The front of the pituitary body is called the anterior pituitary gland, while the back is called the posterior pituitary gland The exact Latin translation of the word pituitary becomes evident from a look at Figure 152 It literally pertains to mucus (MYOO-kus) or phlegm ( em) This term derives from the fact that the pituitary body is located just above and behind the nose Hence, it was only logical for the ancient anatomists to think that the pituitary was the source of the slime (mucus) that sometimes leaks from your nose when its interior is in amed (phlegm)!
Kidney faucet inhibits
Urine flow
Fig 152 The pituitary stalk: A neuroendocrine connection
PART 4 Anatomy and Physiology of Animals
Even though we dwellers of the 21st century realize that the pituitary body is not some kind of channel that carries mucus from the brain down into the nose, we do recognize that there is de nitely a hypothalamus pituitary connection The main connection is through the pituitary stalk But instead of carrying mucus or phlegm, the pituitary stalk contains a network of tiny blood vessels that run down from the hypothalamus into the pituitary body In addition to vital control centers, the hypothalamus also contains an amazing collection of secretory (SEE-kreh-tor-ee) neurons neurons that secrete hormones or hormone-like substances These hormones (or hormone-like substances) are secreted into the tiny blood vessels owing down through the pituitary stalk Thus, the pituitary stalk (and its collection of blood vessels) creates an important neuroendocrine connection This is because the hypothalamus is generally considered part of the nervous system, while the pituitary body and its two glands (anterior pituitary and posterior pituitary) are classi ed as members of the large endocrine gland system One group of secretory neurons produce antidiuretic (an-tee-die-yuh-RETik) hormone Antidiuretic hormone, abbreviated as ADH, is named for its primary function ADH helps the kidney retain water due to its e ect against (anti-) too much urine passing through (diuret) and out of the body Although ADH is actually secreted by the neurons in the hypothalamus, the hormone molecules travel down through the blood vessels in the pituitary stalk, and are then stored by the posterior pituitary gland and later released into the general bloodstream [Study suggestion: Look at the kidney faucet model in Figure 152 How does the de nition of ADH help explain the turning o of the faucet from full blast to a slow drip ]
RELEASING HORMONES AND TROPHIC HORMONES
The largest group of secretions coming from the hypothalamus have no direct connection to ADH These other secretions are called the releasing hormones (RHs) The releasing hormones (RHs) are secreted into the network of tiny brain blood vessels coursing down through the pituitary stalk The transported RHs nally enter the anterior pituitary gland (rather than the posterior pituitary gland) The releasing hormones get their name from their primary function They literally stimulate the release of a variety of trophic (TROHF-ik) hormones from the epithelial cells of the anterior pituitary gland Remember ( 14) that troph means nourishment in the sense of stimulating something Trophic hormones, therefore, are hormones secreted by the anterior pituitary gland that have individual endocrine glands as their
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