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and usefulness of each branch of biophysics to the others Finally, the broad overview of Chaps 2 and 3 will enable us to cover a lot of topics that may not be covered in great detail later in the text, so at least you will understand how they fit into the whole This will be part of your foundation for later learning s 4 through 8 teach the principles of physics, biology, and chemistry that are necessary for a journey into biophysics The focus is on aspects of these sciences that apply most directly to biophysics This includes, in Chaps 4 and 5, an understanding of free energy, the laws of thermodynamics, entropy, and statistical mechanics Next, Chaps 6 and 7 delve into the physical forces that come into play at the molecular level, again paying special attention to those that are most relevant to living things We then review the major categories of biomolecules what they are made of and aspects of their structure and function sort of a quick overview of biochemistry from a biophysical point of view 8 provides an overview of the living cell, its structures, and what these structures do In Chaps 9 through 11 the focus is on subcellular biophysics This is the most common and largest branch of biophysics, and so we go into it in more detail This branch includes protein biophysics, DNA biophysics, and membrane biophysics Finally, Chap 12 explores some aspects of anatomical biophysics, including blood flow and winged flight in animals You can use this book as a self-teaching guide, to lay the foundation for further study or just to satisfy your immediate curiosity It can also be used as a classroom supplement, explaining and clarifying topics that are not as simple in other texts My hope is that in reading this book you will truly find hard stuff made easy Daniel Goldfarb
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Thanks to Judy Bass, my editor at McGraw-Hill, for the opportunity to write this book, and for her advice and guidance throughout; to Dr Kenneth Breslauer, a role-model biophysicist, for coming to my aid on short notice and helping me find a good technical reviewer; and to Pragati Sharma, for her great job in finding errors, and for her valuable suggestions for clarity in many places I especially thank my wife, Sora Rivka, for her sound advice, her encouragement, helping schedule time for me to write, and everything else she did to help make this project possible Finally, I thank my children for their exceptional curiosity, and for always being there (when I was trying to write)
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Biophysics
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Introduction
What is Biophysics
Plain and simple, biophysics is the physics of biology, just as astrophysics is the physics of astronomy and nuclear physics is the physics of atomic nuclei What does this mean What is the physics of biology Physics is the study of matter and energy Biophysics tries to understand how the laws of matter and energy are at work in living systems Another way to say this is that biophysics uses of the principles, theories, and methods of physics to understand biology Biophysics is an interdisciplinary science One could say it is the place where physics, chemistry, biology, and mathematics all meet In practice, most biophysicists study things at the molecular level, but biophysics also includes physiological, anatomical, and even environmental approaches to the physics of living things
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Prerequisites for Biophysics
Biophysics is an advanced science It requires some basic knowledge of biology, physics, chemistry, and mathematics However, since this book is meant as an introduction to biophysics, to demystify biophysics, then as much as possible along the way, I will introduce or review the necessary background information Still, I do need to make some assumption as to your level of understanding in the physical sciences For this purpose I will assume that you have had at least an introductory college-level (or advanced high school level) course in physics or
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