Do genetic factors increase the risk for endometriosis in Android

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Do genetic factors increase the risk for endometriosis
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What three leading theories explain the etiology of endometriosis
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Section II: Topics in Gynecology
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during menses leads to the seeding of endometrial cells in the peritoneal cavity 2 Lymphatic and vascular spread: spread of endometrial cells through lymphatic and vascular channels 3 Coelomic metaplasia: transformation of coelomic epithelium or undifferentiated peritoneal cells into endometrial tissue by an endogenous undefined biochemical factor In what sites are endometrial implants found Most common: ovaries, anterior and posterior cul-de-sac, uterosacral ligaments, posterior uterus, posterior broad ligaments, sigmoid colon, appendix, round ligaments Less common: vagina, cervix, rectovaginal septum, cecum, ileum, inguinal canals, abdominal or perineal scars, ureters, urinary bladder, and umbilicus Rare: breast, pancreas, liver, gallbladder, kidney, urethra, extremities, vertebrae, bone, peripheral nerves, lung, diaphragm, and central nervous system What are the common presenting symptoms of endometriosis and how do ectopic lesions explain these symptoms Chronic pelvic pain: local peritoneal inflammation secondary to formation of adhesions and fibrosis Acute exacerbations of pelvic pain: peritoneal inflammation secondary to the release of hemolyzed blood and other contents of ruptured endometriomas Secondary dysmenorrhea: cyclical changes in ectopic lesions secondary to changes in estrogen levels Dyspareunia: deep infiltration and scarring of the uterosacral ligaments and rectovaginal septum by endometriotic lesions Can also be caused by a retroverted uterus secondary to adhesions (leads to deep dyspareunia)
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4: General Gynecology
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Infertility: invasive endometriosis and the formation of adhesions distorts the normal uterine/tubal/ ovary anatomy, inhibits tubo-ovarian motility, and blocks ovum release Many women are asymptomatic What symptom is pathognomonic for endometriosis What are endometriomas Cyclical rectal bleeding Invasive endometriotic lesions found inside the ovary Often described as a chocolate cyst because it contains old blood that has undergone hemolysis Rupture of endometriomas can cause periteonal inflammation, scarring, and pelvic adhesions Tenderness upon pelvic examination during menses (most common finding) Uterosacral or cul-de-sac nodularity Retroverted uterus and limited motion of ovaries and fallopian tubes Tender, enlarged adnexal mass (unilateral) There are often no abnormal findings on physical examination What is the differential diagnosis for the presentation of endometriosis Pelvic inflammatory disease (PID) Acute or chronic inflammation Ectopic pregnancy Kidney stones Cystitis Pelvic tumors What laboratory tests would help you rule out the diseases on your differential diagnoses list How do the following tests help you in your diagnostic decision making CBC and ESR Positive findings are nonspecific; leukocytosis may be seen in infection Complete blood count (CBC) and erythrocyte sedimentation rate (ESR); cervical Cx; urine -hCG; urinalysis and urine culture
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What are the complications of endometriomas What findings are typically found on physical examination
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Section II: Topics in Gynecology
Cervical Cx Urine b-hCG
Positive cultures for guanylyl cyclase c (GC/C) may indicate PID Positive test indicates pregnancy, ruling out ectopic pregnancy is necessary Ruling out UTI CA125 is not a sensitive diagnostic test for endometriosis (especially in minimal to mild disease) However, it may be used as a marker to follow medical treatment response for endometriosis CA125 levels may decrease during treatment compared to pretreatment values; however, normal posttreatment values do not confirm the absence of endometriosis nor are they useful markers for predicting disease recurrence No However, ultrasound, CT, and MRI are useful for detecting pelvic or adnexal masses (ie, endometriomas) or ruling out other causes of pelvic pain Deeply infiltrating endometriosis that involve the uterosacral ligaments and the cul-de-sac may be detected by MRI Direct visualization by laparoscopy/ laparotomy with histologic confirmation Classic lesions: brown/black/ blue powder burn, gun shot lesions, nodules or small cysts containing old hemorrhage surrounded by fibrosis on the serosal surfaces of the peritoneum Atypical/subtle lesions: clear vesicles, white opacifications, red, white, yellow/ brown plaques, excrescences, scars or lesions of varying sizes Note: Normal appearing peritoneum may have microscopic evidence of endometriosis
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Urinalysis and urine culture What value does CA125 have in the clinical management of endometriosis
Are imaging tests a sensitive modality for diagnosing endometriosis
How is the diagnosis of endometriosis made What are the characteristic findings of endometriosis found during laparoscopy/ laparotomy
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