android barcode scanner api java BURNING AND STINGING SKIN in VS .NET

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CHAPTER 17 BURNING AND STINGING SKIN
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The Role of the Sensory Nervous System
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It is likely that the sensory system in the epidermis is involved in this process, rather than the dermal sensory system In the epidermis, sensory nerves are linked to keratinocytes, melanocytes, Langerhans cells, and Merkel cells (Box 17-1) Sensory nerves are categorized into two groups: the epidermal and the dermal sensory organs It is the epidermally-located Merkel cells that are thought to play a role in sensory perception; however, the exact role of Merkel cells and their possible involvement in mechanosensation is unclear5 Merkel cells consist of neurosecretory granules that contain neurotransmitter-type substances such as metenkephalin, vasoactive intestinal peptide, neuron-specific enolase, and synaptophysin6 The Merkel cell-nerve complex has been called by other names including touch domes, hederiform endings, Iggo s capsule, Pinkus corpuscles, and Haarsheibe Merkel cell-nerve complexes have been found to be associated with hair follicles and eccrine sweat ducts Little is known
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BOX 17-1
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Sensory Nerves in the Skin
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EPIDEMIOLOGY
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Type 3 sensitive skin is common worldwide In a British study, 57% of women and 314% of men reported that they had experienced an adverse reaction to a personal skin care product at some stage
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The super cial skin layer includes sensory nerve bers connected to specialized receptors such as Merkel cells Three types of bers are generally recognized in the sensory subclass of bers: Beta bers, which are the largest bers and myelinated, mediate the touch, vibration, and pressure sensations (conduction velocity of 2 30 m s 1) Delta bers, smaller and myelinated, mediate the cold and pain sensations (conduction velocity of 30 m s 1) C bers, the slowest, smaller and nonmyelinated, mediate the warm and itching sensations (conduction velocity of 2 m s 1) C bers mediate most of the autonomic peripheral functions
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fibers likely play a role because they are known to mediate warm sensations Although the stinging and burning that characterize this skin type are not always associated with inflammation, inflammation may occur as well Neurogenic inflammation may result from neuromediators such as substance P, calcitonin gene-related peptide (CGRP), and vasoactive intestinal peptide, leading to vasodilatation and mast cell degranulation9 Nonspecific inflammation may also be associated with the release of IL-1, IL-8, PgE2, PgF2, and TNF10 Sorbic acid, a known cause of skin stinging, has been found to release prostaglandin D2 (PGD2) from a cellular source in the skin resulting in cutaneous vasodilatation11 Itching seems to be a different process than burning or stinging; however, there may be some overlap A detailed explanation of itching is beyond the scope of this chapter but a good recent review can be found in the study by Steinhoff et al12 An itch response can be experimentally induced by topical or intradermal injections of various substances such as proteolytic enzymes, mast cell degranulators, and vasoactive agents Grove compared the cumulative lactic acid sting scores with the histamine itch scores in 32 young subjects; all the subjects who were stingers were also moderate to intense itchers, whereas 50% of the moderate itchers experienced no stinging13 Recent studies suggest that a new class of C fibers with an exceptionally lower conduction velocity and insensitivity to mechanical stimuli likely can be considered as afferent units that mediate the itchy sensation14
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studies show stingers to have impaired barriers One study examining the relationship between stingers (Baumann S3 type) and those who develop an irritant reaction to a 03% sodium dodecyl sulfate patch test (Baumann S4 type) found that stingers were no more likely to develop an irritant response than nonstingers3
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TABLE 17-1 Ingredients Known to Cause Stinging in Some People Alcohol Avobenzone (Parsol) Azelaic acid Benzoic acid Capsaicin Eucalyptus oil Fragrance Glycolic acid Lactic acid Menthol Peppermint Salicylic acid Sorbic acid Vitamin C Witch hazel
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