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Dermatologist Assessment of Acne Patients
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Change in Parameters of Skin Irritation Baseline to Week 4 05 03 01 -01 -03 Directional results -05
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Patient Self-Assessment of Acne
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Mild Syndet Bar
Significant difference from baseline
FIGURE 31-10 Changes in patient self-assessed skin condition after 4 weeks of using a mild syndet cleansing bar by patients with moderate acne using a topical Rx acne medication (Reproduced from Solodkin G, Chaudhari U, Johnson AW, et al Bene ts of mild cleansing: synthetic surfactant based (syndet) bars for patients with atopic dermatitis Cutis 2006;77:317)
who had enrolled, 33 successfully completed the study On day 1, the subjects were examined by the dermatologist to determine their eligibility for enrollment The study parameters were
evaluated using a 4-point ordinal scoring scale (0 none to 3 severe) In addition to being evaluated by the dermatologist, the subjects were asked to complete a self-assessment question-
naire on the condition of their facial skin at the start of the test Following enrollment, the subjects were instructed to use the syndet bar (in lieu of their normal facial cleanser) to cleanse their face for the next 4 weeks A diary was given to the subjects to document daily use routines and any comments concerning skin reactions The subjects returned to the test facility after 4 weeks At that time, a final skin examination was performed by the dermatologist Also, subjects were asked to complete the skin self-assessment questionnaire (as at the beginning of the test) to monitor their perceived change in skin condition over the 4 weeks of product use Figures 31-10 and 31-11 show the mean change (from baseline to week 4) in dermatologist-assessed and patient self-assessed skin condition for patients on maintenance Retin-A therapy for treatment of facial photodamage Significant improvements in dryness, skin health, skin appearance, softness, and smoothness were observed after using the mild cleansing bar for 4 weeks Results of the clinical studies reported here clearly show that cleansing with a mild synthetic cleansing bar is beneficial for patients with chronic, as well as induced, sensitive skin and validate the need for mild cleansing to be a part of routine fundamental skin care
CHAPTER 31 CLEANSING AGENTS
Patients on Retin-A Maintenance Therapy (4 Weeks of Syndet Bar Use)
04 03
Dermatologist Assessment
Patient Self-Assessment
Mean Change
Mean Change
02 01 0 -01
-02 -03
s lth a g g s g es ea ing es e m e lin gin tc hin htn e nH urn Stin yth I ryn P B D ki Tig Er ll S e ra Ov
FIGURE 31-11 Changes in dermatologist-assessed and patient self-assessed skin condition after 4 weeks of using a mild syndet cleansing bar by patients under maintenance Retin-A therapy for photodamage treatment (Reproduced from Solodkin G, Chaudhari U, Johnson AW, et al Bene ts of mild cleansing: synthetic surfactant based (syndet) bars for patients with atopic dermatitis Cutis 2006;77:317)
s s g e ty ss ss ng ess tion es es nc in e vi hi n a tn gl a iti ryn hne n d s of ear in Itc ght rrit t T S I Re en ll D oo p Ti a lS Ap Sm al ver r ll O ra ve O ve O Significant change from baseline
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