Propylene Glycol in VS .NET

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Propylene Glycol
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Propylene glycol (PG) is an odorless liquid that functions as both a humectant and an occlusive It displays antimicrobial and keratolytic activity PG has been shown to enhance the penetration of drugs such as minoxidil and steroids Although PG is known to be a weak sensitizer itself, it may contribute to contact dermatitis by enhancing penetration by other allergens60
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COLLAGEN AND POLYPEPTIDE INGREDIENTS
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Many expensive moisturizers contain collagen and some manufacturers claim that the collagen in such formulations can replace the collagen lost during the aging process This claim is unfounded, however, because most of the collagen extracts have a molecular weight of 15,000 to 50,000 daltons Only substances with a molecular weight of 5000 daltons or less can penetrate the SC4 The popularity of these products may stem from the fact that the collagen and other hydrolyzed proteins and polypeptides that they contain leave a film on the skin that fills in surface irregularities This is very similar to the way that hair conditioners work Once the product dries, the protein films shrink slightly causing a subtle stretching out of fine skin wrinkles Of course, this effect
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EMOLLIENTS
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These are substances added to cosmetics to soften and smooth the skin They function by filling the spaces between desquamating corneocytes to yield a smooth surface61 These products provide increased cohesion causing a flattening of the curled edges of the individual corneocytes32 This leads to a smoother surface with less friction and greater light refraction Many emollients function as humectants and occlusive moisturizers as well Lanolin, mineral oil, and petrolatum are examples of occlusive ingredients that also confer an emollient effect As suggested above,
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Shea Butter
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Used widely in cosmetic products as a moisturizer, particularly as an emollient, shea butter (Butyrospermum parkii ) is a natural fat derived from the shea or karite tree, which grows naturally across 19 African countries Recent work has revealed that shea butter manifests antiinflammatory activity67 Composed mainly of oleic and stearic acids, shea butter is also notable for containing a higher percentage of unsaponifiables than other vegetable oils68 Shea butter is included and touted in various skin and hair care products, especially high-end skin products, for conferring rich emollient benefits, and is thought to maintain moisture and to provide benefits as an adjuvant moisturizer in the treatment of skin conditions such as atopic dermatitis, dry skin, acne, scars, and striae alba
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the market Such formulations may play a role in maintaining skin barrier function as fluctuations in Ca2 and potassium levels have been shown to influence skin barrier function77 Although these findings are encouraging, they are so recent that no studies evaluating the efficacy of these products had been published as this textbook was being completed New ingredients continuously enter the market as companies are constantly looking for the next new thing ; however, clinical trial data are often nonexistent or remain unpublished as proprietary data by the manufacturers
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Moisturizers are generally very safe, with few reports of side effects Allergic contact dermatitis can result from the use of preservatives, perfumes, solubilizers, sunscreens, and other skin care product constituents Ingredients that may lead to contact dermatitis include fragrances, preservatives, propylene glycol,78 vitamin E,79 and Kathon CG (see s 18, 36, and 37 for more information)
OTHER INGREDIENTS
Many moisturizers contain antioxidants such as vitamins C and E, coffeeberry, green tea, and coenyme Q10 These are popular ingredients because antioxidants are thought to reduce the levels of free radicals attacking the skin and related organs, a process that is thought to contribute to skin aging (see 33) Niacinamide and soy are also popular additives in cosmetic moisturizers (see 34) Another important ingredient is glycyl-L-histidyl-L-lysine-Cu2 (GHK-Cu), a tripeptide-copper complex found in many moisturizers Glycyl-Lhistidyl-lysine is a naturally-occurring tripeptide with a high affinity to copper, which was initially isolated from human plasma69 Copper peptide has been widely used for several years to enhance wound healing GHK-Cu complex has also been demonstrated to enhance collagen synthesis,70,71 and to increase levels of sulfated proteoglycans in fibroblast cultures as well as experimental animal wound models71,72 In addition, it plays a role in tissue remodeling by increasing the levels of matrix metalloproteinase-2 (MMP-2) and tissue inhibitors of MMPs (TIMP-1 and TIMP-2)73 The mechanism of action and research behind this complex have led to its popularity in cosmetic products Although some clinical trials have reported improvement of fine lines and wrinkles with topical use of products containing copper peptide,74 76 more research is warranted to determine the efficacy of copper peptide as an antiaging agent New products that claim to affect calcium and potassium levels have entered
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