zxing barcode generator java example COSMETIC DERMATOLOGY: PRINCIPLES AND PRACTICE in .NET

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Topical vitamin C products must be formulated properly and stored in airtight, light-resistant containers to be effective Skinceuticals, Murad, and La RochePosay have formulated the most effective vitamin C-containing products
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Green tea has been consumed as a popular beverage in Asian countries, in particular, and throughout the world for many years It has recently gained greater popularity in western nations, though, because of its purported antioxidant and anticarcinogenic effects There are numerous in vitro and in vivo studies on the effects of green tea on the skin; in fact, green tea is one of the most studied antioxidants133 Besides its antioxidant activity, green tea polyphenols possess anti-inflammatory and anticarcinogenic properties and modulate the biochemical pathways important in cell proliferation, when administered either topically or orally134,135 Polyphenols are a large, diverse family of thousands of chemical substances found in plants Significantly, many of them are strong antioxidants (Table 34-1) There are four major polyphenolic catechins in green tea: ECG [(-)EpiCatechin3-O-Gallate], GCG [(-)GalloCatechin-3O-Gallate], EGCG [(-)EpiGalloCatechin -3-O-Gallate], and EGC [(-)EpiGallo Catechin] EGCG is the most abundant and biologically active component (Fig 34-5) Special preparation of the tea plant ensures that the antioxidant activities of these polyphenols are preserved White tea, like green tea, comes from the Camellia sinensis plant However, white tea is more expensive because it is harder to obtain White tea actually comes from the tips of the green tea leaves or from leaves that are not yet fully open and the buds are still covered by fine white hair EGCG is the main compound in green and white tea responsible for antioxidant activity136,137 When evaluating the utility of a skin care product, it is necessary to know which polyphenols are in the product EGCG is the most potent form of green tea polyphenols In addition, it is necessary to know what percent of polyphenols
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FIGURE 34-5 Epigallocatechin gallate (EGCG) is the most abundant catechin in tea are in the product The most effective products contain 50% to 90% polyphenols Such formulations are dark in color and look brown when they contain this high level of polyphenols The Replenix line by Topix is an example of a product line with a high level of polyphenols PHOTOPROTECTION BY GREEN TEA In early studies, green tea polyphenols were shown to suppress chemical- and UVinduced carcinogenesis when fed orally or applied topically in hairless or Sencar mice138 140 Other studies have confirmed these results and shown EGCG to be a potent suppressor of photocarcinogenesis141 The profound photoprotective effects of topically applied green tea polyphenols (GTPs) have also been observed in human skin, demonstrating a dose-dependent reduction of UVinduced erythema, decrease in the number of sunburn cells, protection of epidermal Langerhans cells, and limitation of DNA-damage142 Recent studies have demonstrated that GTPs scavenge ROS, stabilizing GPX, catalase, and glutathione, as well as inhibiting nitric oxide synthase, lipoxygenase, COX and xanthine oxidase, and lipid peroxidase In addition, they act as modulators of different gene groups and signal pathways MOLECULAR MECHANISMS OF GREEN TEA Molecular targets of GTPs include among others Ras and AP-1, both of which are involved in the MAPK pathway143 The antiapoptotic effects of EGCG on UVB-
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irradiated keratinocytes seem to be induced by an increase in the expression of the antiapoptotic molecule Bcl-2 and a decrease in the proapoptotic protein Bax144 EGCG has further been shown to reduce UV-induced immunosuppression by limiting IL-10 production and increasing IL-12 production, two major cytokines that mediate UV-induced immunosupression145 In addition, the EGCG-induced IL-12 increase leads to an augmented synthesis of enzymes that repair UV-induced DNA damage146 Also, EGCG seems to reduce UVB-induced immunosuppression by decreasing CD11b, a cell surface marker for activated macrophages and neutrophils in animals treated with UVB147 In mice, EGCG has been shown to downregulate UV-induced expression of AP-1 and NFB and suppress MMPs, which are known to degrade collagen resulting in photodamage148 Prevention of UVinduced oxidative damage and induction of MMPs has been demonstrated in vivo in mouse skin In the study, GTPs were administered in drinking water to SKH-1 hairless mice, which were thereafter exposed to multiple doses of UVB (90 mJ/cm2, for 2 months on alternate days) Treatment with GTPs resulted in inhibition of UVB-induced protein oxidation in vivo in mouse skin, which could also be observed in vitro in human skin fibroblast HS68 cells Further, oral administration of GTPs was shown to inhibit UVB-induced expression of matrixdegrading MMPs in hairless mouse skin, supporting the role of GTPs as antiphotoaging compounds148 GREEN TEA USE IN HUMANS In contrast to the amount of scientific data on GTPs, there are limited studies in human skin examining the topical application of green tea-containing products This is likely caused by the difficulty of designing a study to measure the preventive effects of green tea on aging skin Nevertheless, applying topical GTPs in the morning in combination with traditional sunscreens seems to make sense and is thought to have the potential to protect the skin from UV-induced damage In addition, topical green tea, as is
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