Ginseng in .NET framework

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Ginseng
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Several types of ginseng are found throughout the world, and all are part of the Araliaceae family in the genus Panax (Fig 35-4) The word Panax means all healing, which describes the traditional belief that ginseng manifests properties that heal all the diseased aspects of the body There are several different species of ginseng; two of the most commonly used are P ginseng (Chinese ginseng), popular among Asian cultures, and P quinquefolius (American ginseng), commonly used among Native Americans100 Studies indicate that ginseng may exert chemopreventive properties against cancer Mechanisms behind this assumption include inhibition of DNA damage,101 induction of apoptosis,102 and inhibition of cell proliferation103 There is also evidence that ginseng has potent effects on the inflammatory cascade and may inhibit the inflammation-to-cancer sequence For example, ginsan, a polysaccharide extracted from P ginseng, has been shown to inhibit the release of proinflammatory cytokines in vivo104 Furthermore, the ginsenoside Rg3 has been demonstrated to inhibit the NF- B-mediated induction of the inflammatory process105 In addition, BST204, a fermented ginseng extract, can inhibit inducible nitric oxide synthase (NOS) expression and subsequent nitric oxide production in animal models Finally, ginseng has been proven to inhibit the production of TNF- and other proinflammatory cytokines by cultured macrophages when exposed to bacterial lipopolysaccharides106
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COSMETIC DERMATOLOGY: PRINCIPLES AND PRACTICE
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Licorice Extract
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Licorice (also known as Liquiritae officinalis) is best known in its popular confectionery form of black or red candy Although it is not often thought of as a plant, it is a botanical source of systemic or topical medications that have been used in herbal medicine for approximately 4000 years107 There are different species of licorice; Glycyrrhiza glabra
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FIGURE 35-3 Feverfew
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FIGURE 35-4 Ginseng (Fig 35-5) and Glycyrrhiza inflata (Fig 35-6) are the ones that have displayed the most therapeutic actions, including antiinflammatory properties G inflata is actually the Chinese licorice root, while G glabra grows around the Mediterranean Sea, the Middle East, and central and southern Russia108 G GLABRA Extracts from this more Western species of licorice are an increasingly common ingredient in antiinflammatory products109 Glycyrrhizin is its primary active component, but it also contains polysaccharides and various polyphenols, such as the isoflavone formononetin, which exhibits antioxidant activity110 Glycyrrhetic acid (the biologically active metabolite of G glabra) has been reported to have anti-inflammatory activity in subacute and chronic dermatoses, and therefore has been used to treat eczema, pruritus, contact dermatitis, seborrheic dermatitis, and psoriasis111 In a double-blind study, Saeedi et al evaluated the effect of 1% and 2% topical licorice extract preparations on atopic dermatitis in 60 patients Results indicated that the 2% topical gel was effective in reducing erythema, edema, and pruritus, prompting the researchers to conclude that licorice extract might be effective in treating atopic dermatitis111 Studies have shown that glycyrrhetic acid is able to exert a cortisone-like effect, thus inhibiting proinflammatory PGs and LTs112 However, licorice (glycyrrhetic acid) has not been demonstrated to be superior to topical corticosteroids in treating acute inflammation, such as atopic dermatitis111 The combination of corticosteroids with glycyrrhetic acid has been proven to be effective, however One study displayed effective potentiation of hydrocortisone activity in skin by the addition of 2% glycyrrhetic acid113 In a series of animal studies, Russian scientists found that glyderinine, a derivative of glycyrrhizic acid, exhibited anti-inflammatory, analgesic, as well as antipyretic properties, and concluded that glyderinine is an appropriate ingredient for the treatment of certain skin diseases114 G INFLATA The primary active ingredient of Chinese licorice root is licochalcone A115 a compound that has exhibited anti-inflammatory activity against AAinduced mouse ear edema116 It is found in the Eucerin Redness Relief products In a study assessing the effects of five
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different chalcones, researchers found that four of the five tested chalcones, including licochalcone A, inhibited the production of proinflammatory cytokines from monocytes and T cells The investigators concluded that licochalcone A and some of its synthetic analogues may have immunomodulatory effects, potentially rendering them suitable agents for the treatment of infectious and other inflammatory diseases117 Chalcones also exhibit activity against oxidative stress A study assessing their radical scavenging activity revealed that licochalcones B and D potently delay superoxide anion production118 The long history of traditional uses of licorice root and the track record of positive research in the past few decades make licorice one of the most widely researched plants for medicinal purposes The evidence supporting the medical use of G inflata is slightly less extensive than that of the related species G glabra, but it is similar in terms of the broad range of potential applications
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