Lyral in .NET framework

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Lyral
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The synthetic fragrance hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC, Lyral) is a common allergen that also happens to be used in more than
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50% of marketed deodorants22 Frosch et al tested Lyral (5% in petrolatum) along with the FM I and 11 other fragrances on consecutive patients in six European dermatology departments in 1999 Lyral elicited a positive reaction in 27% of 1855 patients (range 12% 17%) and ranked next to 113% with FM allergy, leading the investigators to call for testing of Lyral in patients thought to be suffering from contact dermatitis23 Geier et al reported on a subsequent test of Lyral 5% in petrolatum in 3245 consecutive patch test patients in 20 dermatology departments, with 19% reacting to the fragrance As part of this study, Lyral and FM I were tested in parallel in 3185 patients, with 94% reacting to FM and 19% to Lyral A reaction to both occurred in 40 patients, corresponding to 133% of those reacting to FM and 678% of those reacting to Lyral As a result of this study, the German Contact Dermatitis Research Group (DKG) opted to include Lyral as part of its standard patch test series24 In 2002, Frosch et al supervised the evaluation of 1855 patients patch tested in six European dermatology centers to determine the frequency of responses to 8% FM and 14 other often used fragrances The six chemicals displaying the greatest reactivity after FM were, in descending order, Lyral, citral, farnesol, citronellol, hexyl cinnamic aldehyde, and coumarin As a precursor to the codification of the FM II, they found these six substances worthy of using in patch testing of contact dermatitis patients, with Lyral as the most notable of these chemicals21 In a recent small study, researchers demonstrated that Lyral causes allergic contact dermatitis in a high percentage of sensitized individuals at usage concentrations typically found in deodorants22 Previously, Lyral had been found to provoke contact allergic reactions in 2% to 3% of eczema patients undergoing patch testing In a small study of 18 eczema patients and seven control subjects, Johansen et al examined a doseresponse relationship of Lyral contact allergy A serial dilution of Lyral in ethanol 6% to 6 ppm was administered to the volar forearm in a 2-week, repeated open application test Upon no reaction to this dosage, cases were tested for 2 additional weeks at a higher dose Eleven cases reacted to the low dose, five to the high, and two to neither There was no reaction to the ethanol vehicle-control Control subjects failed to react to either Lyral concentration or the ethanol vehicle With a
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COSMETIC DERMATOLOGY: PRINCIPLES AND PRACTICE
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statistically significant difference between the groups, the investigators concluded that Lyral was causing skin sensitivity They recommended reductions in usage concentrations to prevent allergic contact dermatitis in response to this fragrance25 In 2006, the North American Contact Dermatitis Group (NACDG) conducted a multicenter study comparing three concentrations of Lyral (5%, 15%, and 05% in petrolatum) to the NACDG screening tray, which includes FM I, balsam of Peru, cinnamic aldehyde, ylang ylang oil, jasmine absolute, and tea tree oil Data collected from 1603 patients at six sites identified balsam of Peru (66%) and FM I (59%) to be the most common patch-test-positive fragrance allergens, followed by cinnamic aldehyde (17%), ylang ylang oil (06%), jasmine absolute (04%), Lyral (04% for 5% Lyral, 03% for 15% Lyral, and 02% for 05% Lyral), and tea tree oil (03%) The investigators concluded that Lyral is an uncommon allergen in North America, and that the 5% concentration should be used in patch tests for patients suspected of having a fragrance allergy26
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TABLE 36-4 The 26 Individual Fragrances Required by the EU Cosmetics Directive (as of March 11, 2005) to be Labeled on Cosmetic Products if Present at 10 ppm in Leave-On Products and 100 ppm in Rinse-Off Products A-isomethyl ionone Amyl cinnamal Amyl cinnamic alcohol Anisyl alcohol Butyl phenyl methyl propional (BPMP, Lilial ) Benzyl alcohol Benzyl benzoate Benzyl cinnamate Benzyl salicylate Cinnamal Cinnamic alcohol Citral Citronellol Coumarin Eugenol Farnesol Geraniol Hexyl cinnamal Hydroxycitronellal Isoeugenol Limonene Linalool Lyral Methyl heptine carbonate Oak moss (Evernia prunastri) Tree moss (Evernia fufuracea)
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