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CHAPTER 36 FRAGRANCE
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-hexylcinnamic aldehyde showed that artificial fragrances can be found in products marketed for its natural ingredients31
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Fragrances are ubiquitous chemical constituents in a significant proportion of the products people use on a daily basis A substantial minority of individuals develop allergic contact dermatitis to at least one of the many hundreds of fragrances used in the wide variety of products that come into contact with the skin In addition, with the advent of aromatherapy, an increasing number of patients have come to enjoy the olfactory sensation that they experience from using such products Ironically, the very ingredients that may bring some therapeutic relief by dint of their scents may cause some irritation to the skin The roster of fragrances in products, as well as the range of products with fragrances added, has expanded as has the list of fragrances included in patch testing for sensitivity since the first allergy to fragrance-based chemicals was identified in 1957 It is important that cosmetic dermatologists and aestheticians be aware of the plethora of chemicals that have been recognized for provoking cutaneous reactions in a distinct but sizable minority of patients
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1 Heydorn S, Johansen JD, Andersen KE, et al Fragrance allergy in patients with hand eczema a clinical study Contact Dermatitis 2003;48:317 2 Nielsen NH, Linneberg A, Menn T, et al Allergic contact sensitization in an adult Danish population: two cross-sectional surveys eight years apart (the Copenhagen Allergy Study) Acta Derm Venereol 2001;81:31
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3 Friedman PS The immunology of allergic contact dermatitis: the DNCB story Adv Dermatol 1990;5:175 4 Orton DI, Wilkinson, JD Cosmetic allergy, incidence, diagnosis, and management Am J Clin Dermatol 2004;5:327 5 Duarte I, Campos Lage AC Frequency of dermatoses associated with cosmetics Contact Dermatitis 2007;56:211 6 Mehta SS, Reddy BS Cosmetic dermatitis current perspectives Int J Dermatol 2003;42:533 7 Jovanovi M, Poljacki M, Duran V, et al c Contact allergy to Compositae plants in patients with atopic dermatitis Med Pregl 2004;57:209 8 de Groot AC, Frosch PJ Adverse reactions to fragrances: a clinical review Contact Dermatitis 1997;36:57 9 Schnuch A, Lessmann H, Geier J, et al Contact allergy to fragrances: frequencies of sensitization from 1996 to 2002 Results of the IVDK Contact Dermatitis 2004;50:65 10 Larsen WG Perfume dermatitis A study of 20 patients Arch Dermatol 1977;113:623 11 Chatard H Case of sensitization to perfumes with cutaneous and general reactions Bull Soc Fr Dermatol Syphiligr 1957;64:323 12 Johansen JD, Andersen KE, Svedman C, et al Chloroatranol, an extremely potent allergen hidden in perfumes: a doseresponse elicitation study Contact Dermatitis 2003;49:180 13 Rastogi SC, Bossi R, Johansen JD, et al Content of oak moss allergens atranol and chloroatranol in perfumes and similar products Contact Dermatitis 2004;50: 367 14 Buckley DA, Wakelin SH, Seed PT, et al The frequency of fragrance allergy in a patch-test population over a 17-year period Br J Dermatol 2000;142:203 15 Bruze M, Johansen JD, Andersen KE, et al Deodorants: an experimental provocation study with cinnamic aldehyde J Am Acad Dermatol 2003;48:194 16 Buckley DA, Basketter DA, Smith Pease CK, et al Simultaneous sensitivity to fragrances Br J Dermatol 2006;154:885 17 de Groot AC, van der Kley AM, Bruynzeel DP, et al Frequency of falsenegative reactions to the fragrance mix Contact Dermatitis 1993;28:139 18 Larsen W, Nakayama H, Fischer T, et al A study of new fragrance mixtures Am J Contact Dermat 1998;9:202
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19 Bruze M, Andersen KE, Goossens A, et al Recommendation to include fragrance mix 2 and hydroxyisohexyl 3cyclohexene carboxaldehyde (Lyral) in the European baseline patch test series Contact Dermatitis 2008;58:129 20 Frosch PJ, Pirker C, Rastogi SC, et al Patch testing with a new fragrance mix detects additional patients sensitive to perfumes and missed by the current fragrance mix Contact Dermatitis 2005;52:207 21 Frosch PJ, Johansen JD, Menn T, et al Further important sensitizers in patients sensitive to fragrances I Reactivity to 14 frequently used chemicals Contact Dermatitis 2002;47:78 22 J rgensen PH, Jensen CD, Rastogi S, et al Experimental elicitation with hydroxyisohexyl-3-cyclohexene carboxaldehydecontaining deodorants Contact Dermatitis 2007;56:146 23 Frosch PJ, Johansen JD, Menn T, et al Lyral is an important sensitizer in patients sensitive to fragrances Br J Dermatol 1999;141:1076 24 Geier J, Brasch J, Schnuch A, et al Lyral has been included in the patch test standard series in Germany Contact Dermatitis 2002;46:295 25 Johansen JD, Frosch PJ, Svedman C, et al Hydroxyisohexyl 3-cyclohexene carboxaldehyde known as Lyral: quantitative aspects and risk assessment of an important fragrance allergen Contact Dermatitis 2003;48:310 26 Belsito DV, Fowler JF Jr, Sasseville D, et al Delayed-type hypersensitivity to fragrance materials in a select North American population Dermatitis 2006;17:23 27 Buckley DA Fragrance ingredient labeling in products on sale in the UK Br J Dermatol 2007;157:295 28 Schnuch A, Uter W, Geier J, et al Sensitization to 26 fragrances to be labeled according to current European regulation Results of the IVDK and review of the literature Contact Dermatitis 2007;57:1 29 Rastogi SC, Johansen JD, Bossi R Selected important fragrance sensitizers in perfumes current exposures Contact Dermatitis 2007;56:201 30 Rastogi SC, Menn T, Johansen JD The composition of fine fragrances is changing Contact Dermatitis 2003;48:130 31 Rastogi SC, Johansen JD, Menn T Natural ingredients based cosmetics Content of selected fragrance sensitizers Contact Dermatitis 1996;34:423
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