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This is by no means an exhaustive list of the skin bioengineering techniques that are available However, these methods are the ones most commonly referred to in the cosmetic dermatology literature Most of these techniques are simple to use and will help physicians collect data on patients that will help various practitioners evaluate the efficacy of the many new cosmetic procedures and treatments available on the market
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Cosmetrics
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Cosmetrics allows cosmetic formulators to test and accurately quantify the effect of a product by extracting data from live skin (Fig 38-6) It was developed as a cosmetic trial management solution to the challenge faced by manufacturers in the skin treatment/product markets, whose consumers increasingly demand proof of product claims Cosmetrics is the only single system
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1 Primavera G, Berardesca E Sensitive skin: mechanisms and diagnosis Int J Cosmet Sci 2005;27:1
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2 Frosch PJ, Kligman AM A method for appraising the stinging capacity of topically applied substances J Soc Cosmet Chem 197;28:197 3 Seidenari S, Francomano M, Mantovani L Baseline biophysical parameters in subjects with sensitive skin Contact Dermatitis 1998;38:311 4 Lahti A Nonimmunologic Contact Urticaria Thesis, Department of Dermatology, University of Oulu and Helsinki, 1980 5 Basketter DA, Griffiths HA A study of the relationship between susceptibility to skin stinging and skin irritation Contact Dermatitis 1993;29:185 6 Grove GL Age-associated changes in intertegumental reactivity In L veque JL, Agache PG, eds Aging Skin: Properties and Functional Changes New York, NY: Marcel Dekker; 1993:189-192 7 Simion FA, Rau AH Sensitive skin Cosmet Toilet 1994;109:43 8 Hannuksela A, Hannuksela M Irritant effects of a detergent in wash and chamber tests Contact Dermatitis 1995;32: 162 9 Mills OH, Berger RS Defining the susceptibility of acne prone and sensitive skin populations to extrinsic factors Dermatol Clin 1991;9:93 10 Maibach HI, Lammintausta K, Berardesca E, et al Tendency to irritation: sensitive skin J Am Acad Dermatol 1989;21:833 11 Pinnagoda J, Tupker RA, Agner T, et al Guidelines for transepidermal water loss (TEWL) measurement Contact Dermatitis 1990;22:164 12 Issachar N, Gall Y, Borell MT, et al pH measurements during lactic acid stinging test in normal and sensitive skin Contact Dermatitis 1997;36:152 13 Takiwaki H, Serup J Measurement of color parameters of psoriatic plaques by narrow-band reflectance spectrophotometry and tristimulus colorimetry Skin Pharmacol 1994;7:145 14 Pi rard GE, Goffin V, Pi rardFranchimont C Corneosurfametry: a predictive assessment of the interaction of personal-care cleansing products with human staratum corneum Dermatology 1994;189:152 15 Pi rard GE, Goffin V, Hermanns-L T, et al Surfactant-induced dermatitis: comparison of corneosurfametry with predictive testing on human and reconstructed skin J Am Acad Dermatol 1995;33:462 16 Charbonnier V, Maibach HI Squamometry In: Chew AL, Maibach HI, eds Irritant Dermatitis Berlin, Germany: Springer; 2006:231-235 17 Pi rard GE, Pi rard-Franchimont C, Saint-Leger D, et al Squamometry: The Assessment of Xerotic by Colorimetry of Dsquame Adhesive Discs Boca Raton, FL: CRC Press; 1996: 18 Pi rard GE, Pi rard-Franchimont C In: Maibach HI, ed Dermatologic Research Techniques: Drug and Cosmetic Evaluations with Skin Strippings Boca Raton, FL: CRC Press; 1996:132-149 19 Pi rard GE EEMCO guidance to the assessment of dry skin (xerosis) and ichthyosis: evaluation by stratum corneum strippings Skin Res Technol 1996;2:3 20 Paye M, Morrison BM Jr Non visible skin irritation Proceedings of the fourth World
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COSMETIC DERMATOLOGY: PRINCIPLES AND PRACTICE
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Surfactant Congress Barcelona, Spain 1996;3:42 Gniadecka M, Serup J Suction chamber method for measurement of skin mechanical properties: The dermaflex In: Serup J, Jemec G, eds Handbook of Noninvasive Methods and the Skin Boca Raton, FL: CRC Press; 1995:329 Paye M, Mac-Mary S, Elkhyat A, et al Use of the reviscometer for measuring cosmetics-induced skin surface effects Skin Res Technol 2007;13:343 Grove G, Grove M, Leyden J Optical profilometry: an objective method for quantification of facial wrinkles J Am Acad Dermatol 1989;21:631 Grove GL Dermatological applications of the magiscan image analysing computer In: Marks R, Payne PA, eds Bioengineering and the Skin New York, NY: MTP Press; 1976:173-80 Grove GL, Grove MJ Objective methods for assessing skin surface topography noninvasively In: L v que JL, ed Cutaneous Investigations in Health and Disease New York, NY: Marcel Dekker; 1988:1-32 Grove GL, Grove MJ Effects of topical retinoids on photoaged skin as measured by optical profilometry In: Packer L, ed
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Methods in Enzymology New York, NY: Academic Press; 1990:360-71 Olsen EA, Katz HI, Levine N, et al Tretinoin emollient cream for photodamaged skin: results of 48-week, multicenter, double-blind studies J Am Acad Dermatol 1997;37:217 Taylor S, Westerhof W, Im S, et al Noninvasive techniques for the evaluation of skin color J Am Acad Dermatol 2006;54:S282 Rajadhyaksha M, Grossman M, Esterowitz D, et al In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast J Invest Dermatol 1995104:946 Langley RG, Burton E, Walsh N, et al In vivo confocal scanning laser microscopy of benign lentigines: comparison to conventional histology and in vivo characteristics of lentigo maligna J Am Acad Dermatol 2006;55:88 Marghoob AA, Charles CA, Busam KJ, et al In vivo confocal scanning laser microscopy of a series of congenital melanocytic nevi suggestive of having developed malignant melanoma Arch Dermatol 2005;141:1401 Busam KJ, Charles C, Lohmann CM, et al Detection of intraepidermal malig-
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nant melanoma in vivo by confocal scanning laser microscopy Melanoma Res 2002;12:349 Torres A, Niemeyer A, Berkes B, et al 5% imiquimod cream and reflectancemode confocal microscopy as adjunct modalities to Mohs micrographic surgery for treatment of basal cell carcinoma Dermatol Surg 2004;30:1462 Horn M, Gerger A, Koller S, et al The use of confocal laser-scanning microscopy in microsurgery for invasive squamous cell carcinoma Br J Dermatol 2007;156:81 Gonzalez S, Rajadhyaksha M, Rubinstein G, et al Characterization of psoriasis in vivo by reflectance confocal microscopy J Med 1999;30:337 Gonzalez S, Gonzalez E, White WM, et al Allergic contact dermatitis: correlation of in vivo confocal imaging to routine histology J Am Acad Dermatol 1999;40:708 Braun RP, Rabinovitz HS, Krischer J, et al Dermoscopy of pigmented seborrheic keratosis: a morphological study Arch Dermatol 2002;138:1556 Astron Clinica Web site http://www astronclinicacom/ Accessed March 8, 2008
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