zxing barcode generator java example COSMETIC DERMATOLOGY: PRINCIPLES AND PRACTICE in Visual Studio .NET


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For centuries, women have noted skin changes following menopause Multiple studies show that women experience decreased skin thickness with a related reduction in the amount of skin collagen that occurs most rapidly in the first five postmenopausal years Skin dryness may be related to decreased levels of hyaluronic acid as well as epidermal thinning For these reasons, oral or topical HRT may be useful to prevent such changes in postmenopausal women While men do not experience the same abrupt decline in sex hormones as women do with menopause, their characteristic hormonal composition also undergoes a decline with age, as witnessed by changes in their skin and other organ systems Whether the skin of elderly men would benefit from hormone replacement, and in what combination, is another vast subject worthy of exploration While estrogen promotes wound healing and testosterone seems to inhibit it, treating men with estrogens long term would certainly have a feminizing effect Perhaps future research into sex hormones and aging skin should focus on hormone
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Sex hormones also influence wound healing It has recently been demonstrated that the mechanism by which estrogen can regulate the production of connective tissue molecules, namely collagen and hyaluronic acid, is by increasing the production of TGF- ,31 a key modulator of wound healing In a randomized, double-blind study by Ashcroft et al that examined the
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The therapeutic benefits of HRT on easing postmenopausal symptoms or improving bone density have been known for many years However, the benefits of HRT on skin aging and wound healing are just beginning to be explored While many postmenopausal women would derive great cutaneous
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receptor or tissue enzyme modulators Currently, most of these agents are being developed and utilized in the field of oncology Hormonal influences on the health and function of skin are an important topic in dermatology that warrant due consideration by the cosmetic practitioner in assessing health or prescreening patients skin prior to performing corrective procedures The beneficial effect of estrogen on collagen production and in the promotion of wound healing is clear Future investigations into the effects of sex hormones on the skin and adnexa are likely to indicate that sex hormones constitute a promising target for therapeutic intervention in both cosmetic and medical dermatology
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1 Liskowski L, Rose DP Experience with a simple method for estrogen receptor assay in breast cancer Clin Chim Acta 1976;67:175-182 2 Bassas E Experimental studies on seborheic alopecia III Localization of testosterone receptors in human hairy follicles Med Cutan Ibero Lat Am 1975; 3:77-79 3 Bulun SE, Takayama K, Suzuki T, et al Organization of the human aromatase p450 (CYP19) gene Semin Reprod Med 2004;22:5-9 4 Simpson ER Aromatase: biologic relevance of tissue-specific expression Semin Reprod Med 2004;22:11-23 5 Genazzani AD, Lanzoni C, Genazzani AR Might DHEA be considered a beneficial replacement therapy in the elderly Drugs Aging 2007;24:173-185 6 Jankowski CM, Gozansky WS, Schwartz RS, et al Effects of dehydroepiandrosterone replacement therapy on bone mineral density in older adults: a randomized, controlled trial J Clin Endocrinol Metab 2006;91:2989-2993 7 Mooradian AD, Korenman SG Management of the cardinal features of andropause Am J Ther 2006;13:145-160 8 Keenan DM, Takahashi PY, Liu PY, et al An ensemble model of the male gonadal axis: illustrative application in aging men Endocrinology 2006;147:2817-2828 9 Mosselman S, Polman J, Dijkema R ER b: identification and characterization of a novel human estrogen receptor FEBS Lett 1996;392:49-53
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10 Thornton MJ, Taylor AH, Mulligan K, et al Oestrogen receptor beta is the predominant oestrogen receptor in human scalp skin Exp Dermatol 2003;12: 181-190 11 Pelletier G, Ren L Localization of sex steroid receptors in human skin Histol Histopathol 2004;19:629-636 12 Pedersen SB, Brunn JM, Hube F, et al Demonstration of estrogen receptor subtypes alpha and beta in human adipose tissue: influences of adipose cell differentiation on fat depot localization Mol Cell Endocrinol 2001;182:27-37 13 Ashcroft GS, Greenwell-Wild T, Horan MA, et al Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response Am J Pathol 1999;155:1137-1146 14 Kanda N, Watanabe S Regulatory roles of sex hormones in cutaneou biology and immunology J Dermatol Sci 2005; 38: 1-7 15 Dekkers OM, Thio BH, Romijn JA, et al Acne vulgaris: endocrine aspects Ned Tijdschr Geneeskd 2006;150:1281-1285 16 Trueb RM Finasteride treatment of patterned hair loss in normoandrogenic postmenopausal women Dermatology 2004;209:202-207 17 Sawaya ME, Price VH Different levels of 5-alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia J Invest Dermatol 1997; 109:296-300 18 Affinito P, Palomba S, Sorrentino C, et al Effects of postmenopausal hypoestrogenism on skin collagen Maturitas 1999;33:239-247 19 Brincat M, Versi E, Moniz CF, et al Skin collagen changes in postmenopausal women receiving different regimens of estrogen therapy Obstet Gynecol 1987; 70:123-127 20 Patriarca MT, Goldman KZ, Dos Santos JM, et al Effects of topical estradiol on the facial skin collagen of postmenopausal women under oral hormone therapy: a pilot study Eur J Obstet Gynecol Reprod Biol 2007;130:202-205 21 Sauerbronn AV, Fonseca AM, Bagnoli VR, et al The effects of systemic hormonal replacement therapy on the skin of postmenopausal women Int J Gynaecol Obstet 2000;68:35-41 22 Castelo-Branco C, Buran M, GonzalezMerlo J Skin collagen changes related to age and hormone replacement therapy Maturitas 1992;15:113-119 23 Brincat M, Versi E, O Dowd T, et al Skin collagen changes in postmenopausal women receiving oestradiol gel Maturitas 1987;9:1-5
24 Pi rard-Franchimont C, Letawe C, Gofin V, et al Skin water-holding capacity and transdermal estrogen therapy for menopause: a pilot study Maturitas 1995; 22:151-154 25 Harvell J, Hussona-Saeed I, Maibach HI Changes in transepidermal water loss and cutaneous blood flow during the menstrual cycle Contact Dermatitis 1992;27: 294-301 26 Creidi P, Faivre B, Agache P, et al Effect of a conjugated oestrogen (Premarin) cream on aging facial skin A comparative study with a placebo cream Maturitas 1994; 19:211-223 27 Fuchs KO, Solis O, Tapawan R, et al The effects of an estrogen and glycolic acid cream on the facial skin of postmenopausal women: a randomized histologic study Cutis 2003;71:481-488 28 Zouboulis CC, Boschnakow A Chronological aging and photoaging of the human sebaceous gland Clin Exp Dermatol 2001;26:600-607 29 Dieudonne MN, Pecquery R, Boumediene A, et al Androgen receptors in human preadipocytes and adipocytes: regional specificities and regulation by sex steroids Am J Physiol 1998;274: C1645-C1652 30 Dieudonne MN, Leneveu MC, Giudicelli Y, et al Evidence for functional estrogen receptors alpha and beta in human adipose cells: regional specificities and regulation by estrogens Am J Physiol Cell Physiol 2004;286:C655-C661 31 Ashcroft GS, Dodsworth J, van Boxtel E, et al Estrogen accelerates cutaneous wound healing associated with an increase in TGFbeta1 levels Nat Med 1997;3:1209-1215 32 Margolis DJ, Knauss J, Bilker W Hormone replacement therapy and prevention of pressure ulcers and venous leg ulcers Lancet 2002;359:675-677 33 Gilliver SC, Wu F, Ashcroft GS Regulatory roles of androgens in cutaneous wound healing Thromb Haemost 2003; 90:978-985 34 Fimmel S, Zouboulis CC Influence of physiological androgen levels on wound healing and immune status in men Aging Male 2005;8:166-174 35 Adzick NS, Lorenz HP Cells, matrix, growth factors, and the surgeon The biology of scarless fetal wound repair Ann Surg 1994;220:10-18 36 Chau D, Mancoll JS, Lee S, et al Tamoxifen downregulates TFG-beta production in keloid fibroblasts Ann Plast Surg 1998;40:490-493 37 Mikulec AA, Hanasono MM, Lum J, et al Effect of tamoxifen on transforming growth factor beta1 production by keloid and fetal fibroblasts Arch Facial Plast Surg 2001;3:111-114
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