zxing barcode generator java example COSMETIC DERMATOLOGY: PRINCIPLES AND PRACTICE in .NET framework

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COSMETIC DERMATOLOGY: PRINCIPLES AND PRACTICE
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While Cordain and others1 have exposed the flaws in the methodologies of the studies that denied a significant link between nutrition and acne, particularly the study by Fulton et al that refuted a connection between chocolate and acne, such debunking has not undermined the basic truth happened upon more than 30 years ago regarding acne and chocolate Cordain pointed out that the actual treatment variable in the Fulton study was an ingredient of the tested bittersweet chocolate candy bar, cacao solids, which were replaced with partially hydrogenated vegetable fat in the control bar While suggesting that the only logical conclusion of this study was that cacao solids may not contribute to the causal pathway of acne, he also noted, among other criticisms, that because subjects also consumed their normal diets in addition to the 112-g test or control bar daily for 4 weeks with no baseline measurements, there was no way of determining the quantity of cacao solids consumed in either arm of the study6 Indeed, it is likely that it is the sugar that is added to various chocolate delicacies that engenders multiple deleterious health effects if consumed with regularity and over time, not the cacao or chocolate ingredient Evidence suggests that sugar and sugar products may promote such cutaneous effects through the glycosylation of proteins in the skin,36,37 ultimately leading to skin wrinkling and photoaging (see s 2 and 19)
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In 1961, Hitch and Greenburg disproved the notion of a direct causal connection between acne and iodine intake as the largest quantities of fish and other seafood were consumed by adolescents who exhibited the lowest acne rates in their study25 However, in 1967, Hitch did establish that iodine consumption can aggravate acne26 In response to the Adebamowo et al study on an association between dairy intake during high school and teenaged acne cited above, Arbesman indicated that the iodine content of milk may have also contributed to acne development in addition to the hormonal explanation proffered by the investigators27 He added that significant
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Interestingly, rather than serving as a culprit in acne pathogenesis, chocolate has a history dating back at least since the 1500s as a component in the medical practices of the Olmec, Maya, and Aztec peoples38 Not only does chocolate per se not directly cause acne (though a steady diet of highly-sugared chocolate products can certainly contribute to it), the Borba product line now includes a Clarifying Chocolate Bar made with Swiss dark chocolate that is touted for its patented formula that is said to have the opposite effect on skin actually clearing skin or preventing breakouts Of course, a healthy dose of skepticism regarding the potential contributory effects of a particular food toward acne is just as appropriate toward the notion of consuming a supposedly healthier item to exert the opposite effect A consistent pattern of good nutrition is likely the optimal choice for overall health, total cutaneous health, and reducing the risk of developing acne It has long been known that a diet rich in fruits and vegetables is ideal Much has been learned in recent decades, though, regarding the chemical constituents in such foods that may play direct roles in health, including the health of the skin The beneficial activities exhibited by certain chemical ingredients in foods have, in turn, been harnessed in various medications to exert more direct effects For instance, retinoids are a form of vitamin A, which has long been known to play a role in acne Notably, carotenoids are one of the best dietary sources of vitamin A
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Certain plant constituents have been established as exerting photoprotective effects as antioxidants, including carotenoids, flavonoids and other polyphenols, tocopherols, and vitamin C In a recent study, Stahl et al demonstrated that consumption of lycopene, which is the primary carotenoid in tomatoes and is also present in apricots, papaya, pink grapefruit, guava, and watermelon, was effective in preventing or curbing sensitivity to ultraviolet (UV)-induced erythema formation in volunteers consuming lycopene-rich products over 10 to 12 weeks39 Stahl et al previously investigated whether the use of dietary tomato paste, a rich source of lycopene, could deliver a protective effect against UV-induced erythema in humans A solar simulator was used to induce erythema in the scapular area at the outset of the study
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and after weeks 4 and 10 For a period of 10 weeks, 9 volunteers ingested 40 g of tomato paste with 10 g of olive oil while 10 controls ingested olive oil only Carotenoid levels were equivalent between the two groups at the beginning of the study and there were no significant differences between the groups at week 4 There was neither change in serum carotenoids in the control group by week 10 nor in other carotenoids but lycopene in the experimental group, but those consuming tomato paste exhibited higher serum levels of lycopene accompanied by scapular erythema development 40% less than controls40 In subsequent experiments that involved daily ingestion of tomato paste (16 mg/d) for 10 weeks, Stahl and Sies demonstrated similar results, with increases measured in serum levels of lycopene and total carotenoids in skin and significantly less erythema formation after 10 weeks They also determined that there is an optimal level of protection associated with each carotenoid micronutrient41 In a placebo-controlled, parallel study involving some of the same investigators, the protective effects against erythema of beta-carotene (24 mg/d) were compared to those of the same dose of a carotenoid combination of beta-carotene, lutein, and lycopene (8 mg/d each) or placebo for 12 weeks Erythema intensity before and 24 hours after irradiation with a solar light simulator was recorded at baseline and following 6 and 12 weeks of supplementation Researchers noted diminished intensity in erythema 24 hours after exposure (at weeks 6 and 12) in both experimental groups, with substantially less erythema formation after 12 weeks in comparison to baseline While there were no observed changes in the control group, serum carotenoid levels increased significantly also, three- to four-fold in the betacarotene group and one- to three-fold in the mixed carotenoid group42 In a more
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recent study by several of the same investigators, the photoprotective effects of synthetic lycopene were compared to the effects of a tomato extract (Lyc-o-Mato) and a beverage containing solubilized Lyc-o-Mato (Lyc-o-Guard-Drink) after 12 weeks of supplementation Significant increases were observed in all groups in terms of serum levels of lycopene and total skin carotenoids and a protective effect against erythema formation was seen in all groups as well, but it was substantially larger in the Lyco-o-Mato and Lyc-o-Guard groups The researchers speculated that the carotenoid phytofluene and carotenoid precursor phytoene may have assisted in providing this additional photoprotection43 Finally, lutein and zeaxanthin, found in leafy green vegetables, were supplemented for 2 weeks in the diets of female hairless Skh-1 mice to determine the cutaneous response to UVB Investigators observed significant reductions in the edematous cutaneous response as well as decreases in the UVB-induced elevation in hyperproliferative markers44
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