EPA/DHA, Immunoresponse and Psoriasis in VS .NET

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EPA/DHA, Immunoresponse and Psoriasis
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DHA has been shown to inhibit inflammation and immunoresponses in the contact hypersensitivity reaction in mice Investigators fed dietary DHA as well as EPA to mice sensitized with 2,4-dinitro1-fluorobenzene They found that 24 hours after the contact hypersensitivity challenge, ear swelling was reduced by DHA ethyl ester, but not EPA ethyl ester DHA also diminished the infiltration of CD4+ T lymphocytes into the ears, and minimized the expression of interferongamma, interleukin (IL)-6, IL-1beta, and IL-2 mRNA in the ears The researchers concluded that the immunosuppressive activity associated with fish oil should be ascribed primarily to DHA and not its fellow n-3 PUFA64 However, in clinical trials, EPA and DHA in fish oils have, combined with medication, been shown
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to ameliorate the skin lesions, reduce the hyperlipidemia caused by etretinates (which were removed from the Canadian market in 1996 and the US market in 1998 because of elevated risks of birth defects), and lower cyclosporin toxicity in patients with psoriasis65 Furthermore, in a 14-day double-blind, randomized, parallel group multicenter study in which 83 patients hospitalized for chronic plaque-type psoriasis (with a Psoriasis Area and Severity Index [PASI] score of at least 15) were randomized to receive daily intravenous administration of either an omega-3 fatty acid-based lipid emulsion or an omega-6 emulsion, investigators observed greater improvements in the omega-3 group in terms of diminished psoriasis severity, which was echoed by patient self-assessment The researchers concluded that chronic plaque-type psoriasis could be effectively treated with intravenous omega-3 fatty acids66
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Dry Skin
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Fifteen years ago, investigators studied 79 vegetarians (51 females, 28 males) and 79 age- and sex-matched nonvegetarians to assess the relative antioxidant/atherogenic risks Plasma alpha-tocopherol and corresponding cholesterol values were found to be significantly lower in the vegetarians as was their risk for atherosclerosis, but their tocopherol-to-cholesterol molar ratio was significantly increased67 Such results explain the higher incidence of dry skin in vegetarians Cholesterol is an important substance in maintaining a balance in the oily dry continuum With more vitamin E and less cholesterol, vegetarians are more likely to experience dry skin (see s 11 and 32) In a 6-week study of the mechanisms and efficacy of n-3 PUFA for the treatment of atopic dermatitis (AD), investigators administered various formulas of ALA in NC/Nga mice with AD, and found that concentrations of n-3 fatty acids increased and n-6 fatty acids decreased in the red blood cell membranes, prostaglandin E(2) production was decreased, and skin blood flow was altered, increasing in the ear of mice treated with the highest dose of ALA The researchers, noted, however, that AD development was not prevented59
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MATCHING DIETARY NEEDS WITH SKIN TYPE
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The Baumann Skin Typing System (BSTS), introduced in The Skin Type Solution (Bantam 2005), is a novel approach to classifying skin type (see 9) The BSTS score, derived from a self-administered questionnaire, is based on the understanding that skin can be assessed according to four major parameters: oily versus dry (O/D), sensitive versus resistant (S/R), pigmented versus nonpigmented (P/N), and wrinkled versus tight (W/T) Sixteen different skin type permutations are possible The discussion of dietary needs based on skin type proceeds according to the four major parameters The center of the spectrum is ideal for both the O/D and S/R parameters Dietary interventions appear to be possible to render skin less oily or dry, as well as less sensitive, but not less resistant Sensitive skin will be discussed briefly in the OSNW Skin Type section below, but primarily in the context of comparing vegetarian and nonvegetarian diets and nutritional approaches to curbing inflammation, which is a fundamental presentation of all sensitive skin subtypes Regarding the P/N and W/T parameters, the N and T poles are the ideals While various photoprotective behaviors are recommended to achieve these ends, particularly regarding the W/T spectrum, there appear to be dietary interventions that will promote or support these skin types
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