NUTRITION AND THE SKIN in .NET

Painting QR Code ISO/IEC18004 in .NET NUTRITION AND THE SKIN

CHAPTER 8 NUTRITION AND THE SKIN
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Hyaluronic Acid
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One of the three primary constituents of the dermis, HA, also known as hyaluronan, is the most abundant glycosaminoglycan in the human dermis HA, which has the capacity to bind water up to 1000 times its volume, plays an important role in cell growth, membrane receptor function and adhesion Its main biologic function in the intercellular matrix is to stabilize intercellular structures and form the elastoviscous fluid matrix in which collagen and elastin fibers are firmly enveloped122,123 HA holds onto moisture, as well, and helps provide fullness and radiance to the skin While HA is the main component of several effective and popular dermal filling agents, and has also demonstrated efficacy as an intra-articular injection agent for knee osteoarthritis,124 oral HA supplements are also available These products are touted for combating the decline of HA, which occurs with age However, HA is metabolized in the stomach; therefore, the author does not believe there is any evidence demonstrating the effectiveness of these supplements
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Horse Chestnut Seed Extract
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Of the various species of horse chestnuts, trees as well as bushes, the European horse chestnut (Aesculus hippocastanum) is the one used most often for medicinal purposes In its oral form, horse chestnut seed extract (HCSE) has been shown to effectively enhance circulatory problems such as varicose veins and leg cramping Indeed, researchers conducting a thorough literature review of double-blind, randomized controlled
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Iron
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Found in every cell of the body, iron is an important mineral for all-around good health and is essential in the production of hemoglobin, the blood component that distributes oxygen throughout the body Low iron levels have been associated with hair loss
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Glucosamine
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Typically derived from the shells of shellfish (although synthetic versions
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Supplementation could help control or resolve this condition Iron deficiency may also manifest in the fingernails, as white spots or vertical ridges Physicians should check a patient s ferritin levels prior to recommending an iron supplement Excess iron can generate free radicals, which attack vital skin constituents, such as collagen and elastin, and accelerate cutaneous aging Iron supplements should be recommended to patients only if it is determined that they have low iron levels Good dietary sources of iron include dried beans, dried fruits, egg yolks, salmon, tuna, whole grains, and other foods
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controlled, parallel study design to exert a comparable improvement in mitigating UV-induced erythema in humans as 24 mg of beta-carotene alone42 More recent work by some of the same investigators has further buttressed the evidence showing the photoprotective effects of lycopene supplementation, with significant increases measured in lycopene serum levels and total skin carotenoids; erythema was also demonstrably prevented after UV irradiation43 More research is necessary, but lycopene, through oral supplementation or topical administration, is also considered a potential chemopreventive agent of nonmelanoma skin cancer126
Lycopene
Naturally present in human blood and tissues, lycopene is a non-provitamin A carotenoid best known as the pigment mainly responsible for the characteristic red color of tomatoes During the last decade, lycopene has garnered much attention for its potent antioxidant activity125,126 Lycopene may play a role in reducing oxidative damage to tissues, as suggested by a placebo-controlled study that examined the effects on plasma and skin concentrations of betacarotene and lycopene from ingesting a single 120-mg dose of beta-carotene The effects from UV light exposure were also examined Lycopene levels in plasma and skin, which are comparable or greater than those of beta-carotene, were unaffected by beta-carotene ingestion, but beta-carotene levels increased Furthermore, a single intense exposure (3 times the MED) of solar-simulated light on a small area of the volar arm resulted in a 31% to 46% decrease in skin lycopene concentration, but no significant changes in skin beta-carotene, which led the investigators to conclude that lycopene may contribute to absorbing or mitigating the effects of UV radiation and other forms of oxidative insult127 Recently, protection against erythema development after UV exposure has been demonstrated as a result of increasing lycopene intake by daily consumption of tomato paste for a 10-week period125 Consequently, Sies and Stahl, who conducted the study, have deemed lycopene an effective oral sun protectant that can play an important role in maintaining the health of the skin In work published by these and additional investigators in the same year, supplementation for 12 weeks with 24 mg/d of a carotenoid formulation including beta-carotene, lutein, and lycopene was found in a placebo-
duced extended-release 1000 mg niacin ER tablet has been shown to reduce the frequency, duration, and intensity of niacin-induced flushing132 Although niacin supplements may be prescribed for various conditions, there is no skinrelated reason to take more than what would be derived from a typical multivitamin Niacinamide, in contrast, imparts no cutaneous side effects and is a very effective ingredient in topical formulations for treating photodamage, inflammation, hyperpigmentation, and dry skin Niacinamide is found in the Olay brand products such as Total Effects, Regenerist, and Definity The brand Nia24 contains an ingredient very similar to niacinamide
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