Polypodium Leucotomos in Visual Studio .NET

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Polypodium Leucotomos
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Derived from the fern family, the extract of Polypodium leucotomos has been used to treat inflammatory conditions and shown, in vitro and in vivo, to display inmunomodulating activity139 It is also thought to exhibit potent antioxidant activity and is considered a viable oral photoprotectant140,141 In 2004, Middelkamp-Hup et al assessed whether oral Polypodium leucotomos extract (PLE) could diminish the clinical and histologic phototoxic damage to human skin caused by psoralen with ultraviolet A (PUVA) treatment Ten healthy patients with skin types II to III were exposed to PUVA alone and PUVA accompanied by 75 mg/kg of oral PLE After 48 to 72 hours, clinical results revealed consistently lower phototoxicity in PLE-treated skin, with pigmentation reduced 4 months after treatment Histologic examination indicated significantly fewer sunburn cells, and reductions in vasodilatation and the tryptasepositive mast cell infiltration, in addition to preservation of Langerhans cells in PLE-treated skin The authors found that PLE effectively protected the skin against the known deleterious effects of PUVA142 Although this was a small study, the results spurred the team to additional study of PLE In research reported later in 2004 by the same group, nine healthy individuals, with skin types II to III were exposed to various doses of artificial UVR radiation without or following oral administration of 75 mg/kg PLE Investigators assessed erythematous reactions 24 hours after exposure and obtained paired biopsy specimens from PLE-treated skin and untreated skin Significantly less erythema was noted in the PLEtreated skin In the biopsy specimens, researchers recorded fewer sunburn cells, cyclobutane pyrimidine dimers, and proliferating epidermal cells as well
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as less mast cell infiltration Preservation of Langerhans cells was also achieved The team s previous findings were supported by this study, which prompted them to conclude that oral PLE effectively protects the skin against UV insult143 In a study by Middelkamp-Hup et al of the potential of oral PLE in the treatment of vitiligo vulgaris, 50 patients were randomly administered 250 mg of oral PLE or placebo 3 times daily, combined with the first-line therapy (narrow-band UVB) twice weekly for 25 or 26 weeks Investigators identified a definite trend in repigmentation in the head and neck area, particularly in light skin types, with the combined narrow-band UVB and oral PLE therapy144 PLE is most widely available in a capsule supplement known as Heliocare It is expensive, but it helps protect the skin against UV damage, and reduces erythema caused by sun exposure The author recommends one capsule taken in the morning when sun exposure is anticipated, two capsules if the exposure is expected to be prolonged
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CHAPTER 8 NUTRITION AND THE SKIN
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Selenium
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An important antioxidant, selenium is a trace mineral found naturally in the body and various foods, particularly Brazil nuts Some seafood, meat, cereals, and dairy products contain selenium as do several plant foods, depending on the selenium content of the soil in which they are grown Selenium is essential to good health, but required in only small amounts145 A properly functioning thyroid is also dependent on selenium In addition, the protective activity characteristic of the immune cells is supported by the synergistic cooperation of various vitamins and minerals, including selenium146 Although a capacity to protect against skin cancer has been recently disproved, selenium remains among the list of potential oral or topical chemopreventive agents against other forms of cancer,126 and it is considered an important contributor to antioxidant defense135,147 However, in a recent prospective case-cohort study of the link between arsenic-related premalignant skin lesions and prediagnostic blood selenium levels in 303 cases newly diagnosed from November 2002 to April 2004 and 849 subcohort members randomly selected from the 8092 subjects in the Health Effects of Arsenic Longitudinal Study, investigators found that dietary selenium intake may lower the incidence of arsenic-related
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premalignant skin lesions among susceptible populations (those exposed to arsenic from drinking water)148 In addition, it is thought to exhibit potent antiinflammatory and antiaging properties and, in oral form, appears to mitigate UV-induced skin damage Although more research is necessary, selenium in both oral and topical form appears to impart several benefits to the skin It is used as a topical water to treat psoriasis, eczema, and other inflammatory skin conditions in the La Roche-Posay spa in France dedicated to the treatment of these skin conditions Most multivitamins typically contain a sufficient amount of selenium The recommended daily allowance of selenium for adults is 55 g, and overdose can be harmful (generally, more than 400 g/d) In fact, excessive amounts of selenium can lead to hair loss
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found in a good multivitamin It is healthier, however, to derive one s necessary vitamin A through diet, particularly by eating leafy greens, carrots, cantaloupes, sweet potatoes, spinach, broccoli, squash, and mangoes
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