Vitamin C in .NET

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Vitamin C
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Known historically for its role in the prevention of scurvy, vitamin C is abundantly available in citrus fruits In fact, by the 18th century, sailors knew that eating citrus fruits prevented this condition associated with dental abnormalities, bleeding disorders, characteristic purpuric skin lesions, and mental deterioration In the 1930s, researchers confirmed that vitamin C is the key ingredient in citrus fruit that fends off scurvy, and dubbed it ascorbic acid (scobutus is Latin for scurvy) Currently, vitamin C is considered a potent antioxidant and is used effectively as an antiaging and antiinflammatory agent In the skin, vitamin C plays an integral role in the metabolism of collagen, where it is essential for the hydroxylation of lysine and proline in procollagen (see 2) Vitamin C has also been demonstrated to augment collagen synthesis in both neonatal and adult fibroblasts when added to culture medium154 Aging skin is characterized by decreased collagen production (see 6) Consequently, it is thought that increasing collagen production in the skin with vitamin C should theoretically contribute to preventing or even reversing some of the signs of cutaneous aging155 The stimulatory effects of vitamin C on collagen synthesis are believed to be effective in preventing and treating striae alba (stretch marks) This important role in collagen synthesis indicates the relevance of vitamin C in wrinkle prevention In a literature review of the photoprotective effects of vitamins C and E, investigators found that topical applications of each individual antioxidant performed significantly better than their orally administered counterparts The photoprotective effects of vitamin C and E combinations, along with other antioxidants, proved to be markedly more effective than monotherapies in delivering cutaneous protection against UVB156 In a 3-month study of the effects of oral administration of a combination of vitamins C and E, investigators found significant decreases in the sunburn response to UVB exposure, with substantially fewer thymine dimers induced by UV radiation, implying a
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Vitamin A
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Retinol, also known as vitamin A, has such status because it is not synthesized in the human body The term retinoids refers to vitamin A and all its natural and synthetic derivatives including retinol Carotenoids such as carrots, cantaloupes, sweet potatoes, and spinach are among the best dietary sources of vitamin A149 Milk, margarine, eggs, beef liver, and fortified breakfast cereals are also important dietary contributors of vitamin A150 The retinoids exhibit several important biologic effects, such as regulating growth and differentiation of epithelial cells, inhibiting tumor promotion during experimental carcinogenesis, diminishing malignant cell growth, decreasing inflammation, and enhancing the immune system151 (see 30) Retinoids have also been shown to improve the appearance of striae and improve skin discoloration152 Vitamin A is also particularly beneficial for individuals with acne, as it helps diminish oil levels in the skin In addition, retinoic acid, or tretinoin, is known to reverse the signs of photoaging by diminishing wrinkles, actinic keratoses, and lentigines as well as smoothing skin texture153 In cooperation with several other vitamins and minerals, including vitamins C and E, as well as zinc, vitamin A contributes to enhancing skin barrier function as well as immune cell protective activity146 Vitamin A is an important part of any diet, but consuming or taking excessive amounts poses risks, including a greater susceptibility to bone fracture There is rarely a reason to take more than what is
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protective effect against DNA damage conferred by the antioxidant combination157 In a more recent study of the effects of the oral administration of a mixture combining the antioxidants vitamins C and E, Pycnogenol, and EPO on UVB-induced wrinkle formation, female SKH-1 hairless mice received the test mixture or control vehicle for 10 weeks along with UVB irradiation 3 times weekly, with graduated increases in UVB intensity Investigators found that UVB-induced wrinkle formation was significantly inhibited, with substantial reductions also seen in epidermal thickness as well as UVBengendered acanthosis, hyperplasia, and hyperkeratosis158 Many physicians, including the author, recommend that patients take oral vitamin C 500 mg twice daily This way they enjoy the benefits of vitamin C without the irritation and expense of topical formulations, which are difficult to stabilize Other than an upset stomach, there is no risk of taking too much vitamin C
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