Zinc in .NET framework

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Zinc is an essential trace element found in, but not produced by, the human body It is present in various foods, particularly high-protein meats such as lean
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beef, chicken, and fish A vegetarian diet often contains less zinc than a meatbased diet Good vegetarian sources of zinc include beans, dairy products, lentils, nuts, seeds, particularly pumpkin seeds, whole grain cereals, and yeast173 Only known as an essential dietary factor for 40 years, zinc is now also thought to exhibit antioxidant and anti-inflammatory activity174 In addition, zinc assists other micronutrients in bolstering the function of the skin barrier as well as the protective actions of immune cells146 Zinc is also necessary for synthesizing retinol binding protein, which transmits vitamin A Although there are no areas in the body where zinc is stored, the essential mineral is found in muscle (60%), bone (30%), skin (5%), and other organs173,175 The beneficial effects on immunity are typically cited as the reason for the inclusion of zinc in various cold and flu overthe-counter remedies Indeed, antiviral effects are now being considered In a placebo-controlled trial reported on in 2002, investigators found oral zinc sulfate at a dose of 10 mg/kg daily to be successful for the treatment of recalcitrant viral warts after a follow-up of 2 to 3 months176 The overlapping, protective roles of the skin and the immunity system appear to be reflected in the activity of zinc In a recent study of the effects on the allergic response of zinc deficiency in a DS-Nh mouse model of atopic dermatitis, investigators fed male mice a zinc-deficient diet for 4 weeks and found that zinc deficiency affects the skin barrier and immune systems, and aggravated atopic dermatitis177 With age, zinc absorption declines and zinc deficiency is not uncommon in the elderly, particularly individuals older than 75 years175 Zinc supplementation has been shown to reverse the plasma zinc reductions, plasma oxidative stress marker increases, and elevated production of inflammatory cytokines seen in the elderly174 The adult recommended daily amount (RDA), now referred to as the reference nutrient intake (RNI), for zinc is 15 mg/d for men and 12 mg/d for women, though pregnant women require more zinc It is important to note that only 20% of the zinc present in the diet is actually absorbed by the body In addition, zinc absorption is often impaired in patients with chronic GI inflammation For oral mineral supplements, the amounts of zinc and iron should be equivalent so that they do not interfere with absorption Zinc is lost primarily through feces, urine, hair, skin, sweat, semen, and menstrual blood
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Diet plays a crucial role in the appearance of the skin and plays a role in everything from skin hydration, redness, and acne to cutaneous aging Even broken blood vessels on the face can be caused by diet Based on the studies reviewed above, certain dietary principles can be gleaned and formulated into suggestions for patients regarding general cutaneous health as well as specific concerns such as which foods to eat or avoid in an antiaging or acne treatment regimen The following discussion provides some general dietary guidelines for healthy skin (Box 8-1) as well as some specific recommendations that depend on skin type (Box 8-2) The following dietary recommendations are long-term interventions intended for good overall health and the prevention of future wrinkles, not as treatment for already extant wrinkles
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Fish and Omega-3 Fatty Acids
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As stated above, predatory fish such as albacore tuna, lake trout, mackerel, menhaden, and salmon are high in omega-3 fatty acids Salmon, in particular, is highly regarded and readily available, as is tuna Salmon contains omega-3 and omega-6 fatty acids that help human skin hold onto water, inhibiting transepidermal water loss The numerous omega-3 fatty acids in salmon (particularly EPA and DHA) are also anti-inflammatory; therefore, eating salmon may help curb acne and facial redness Patients should be advised to select wild salmon because it may have a greater abundance of omega3 fatty acids and fewer contaminants, such as PCB, as compared to farmed salmon The author recommends eating salmon at least 3 times a week Omega-3 fatty acids as well as omega-6 fatty acids are essential for healthy human growth and development The typical Western diet had a typical ratio of omega6 to omega-3 fatty acids of 10:1 during the mid-1990s,178 which has now increased to a range of approximately 15:1 to 167:1179 A healthy ratio is thought to be closer to 4:1178 A high ratio of omega-6 to omega-3 fatty acids has been associated with a greater risk for depression and various inflammatory diseases180 Omega-3 fatty acids exhibit significant anti-inflammatory activity Good sources of omega-3 fatty acids, in addition to the fish mentioned above, are cod liver oil, fish oil, flaxseeds, and flaxseed oil Crushed or ground flaxseeds can make a healthy complement to yogurt or oatmeal Flaxseed oil
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BOX 8-1 General Dietary Recommendations in Brief Eat salmon at least 3 times per week Add axseeds to your diet or use axseed oil as a salad dressing Eat foods high in antioxidants, such as a wide variety of berries and pomegranates Eat a wide variety of fruits, vegetables, and legumes what nutritionists have been advising for decades In particular, eating fruits and vegetables that are in season is more nutritious 5 Use spices such as oregano, ginger, and basil, all of which exhibit antioxidant properties 6 Drink 2 to 4 cups of green tea per day 7 Drink plenty of water (1 to 2 L a day, depending on level of exertion, humidity conditions, and individual need) 8 Supplement with CoQ10, at least one 200 mg gel cap in the AM 9 Drink a moderate amount of red wine, which contains the polyphenolic antioxidants resveratrol and grape seed extract, both of which confer signi cant antiaging bene ts Consumption of too much alcohol leads to free radical formation, which ages the skin 10 Limit or avoid calorie-dense re ned sugars, saturated fats, and processed foods Sugar can contribute to acne and accelerate aging by causing the glycosylation of necessary proteins 11 Following the premise that what is good for the digestion is good for the skin, eat smaller portions (the typical American diet, particularly as evidenced by restaurant portions, overdoes this considerably), and chew slowly (ideally not while reading, watching TV, or otherwise distracted) It is important to note that these are general guidelines Individual dietary needs may vary In fact, the BSTS system is founded on the notion that skin care needs vary according to skin type (See Table 8-8 for oral supplementation guidelines by BSTS) Accordingly, some dietary needs or restrictions can be categorized by skin type It is worth noting that ancient medical systems that continue in the present day traditional Chinese medicine and Ayurveda, from the Indian subcontinent base nutritional advice on evaluations of an individual s constitution and their relative de cits upon examination Ultimately, as we are learning in the West, one healthy diet plan does not t all individual tailoring is necessary For Vegetarians: To achieve the optimal level of essential fatty acid intake, vegetarians should follow these practical guidelines: (1) Make a wide variety of whole plant foods the foundation of the diet (2) Derive the majority of fat from whole foods nuts, seeds, olives, avocados, and soy foods (3) If using concentrated fats and oils, select those rich in monounsaturated fats, such as olive, canola, or nut oils Oils rich in omega-3 fatty acids can also be used but should not be heated Moderate use of oils rich in omega-6 fatty acids is advised (4) Limit or avoid intake of processed foods and deep-fried foods rich in trans and omega-6 fatty acids (5) Reduce intake of foods rich in saturated fat (6) Include foods rich in omega-3 fatty acids in the daily diet (ideally consuming 2 4 g ALA/d) (7) Consider using a direct source of DHA, ideally 100 to 300 mg/d 1 2 3 4
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TABLE 8-8 Oral Supplement Recommendations by BSTS Parameter SKIN TYPE PARAMETER Dry SUPPLEMENT Borage seed oil Cholesterol Evening primrose oil Glucosamine Omega-3 fatty acids Vitamin A Fish oils, marine oils (omega-3 fatty acids, particularly eicosapentaenoic acid and docosahexaenoic acid) NA Pycnogenol Vitamin C Soy NA Coenzyme Q10 Green tea Pomegranate Pycnogenol Vitamin C Vitamin E NA
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