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The sensory reactivity test focuses on the neurosensory component of the sensitive skin response The most popular has been the sting test,34 in which lactic acid or other agents including capsaicin, ethanol, menthol,35 sorbic acid, and benzoic acid36 are applied to the skin (see s 17 and 38)
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To test for this type of skin, an irritant reactivity test is performed This is also called a patch test In this test, an irritant or allergen is applied to the skin for a certain amount of time, usually 48 to 72 hours, and objective measures of irritation such as erythema and scaling are gauged Primary irritants such as SLS or suspected allergens may be applied (see 18)
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For years, the rabbit ear model was used to test cosmetic ingredients for their potential to cause comedones30,31 Based
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Sensitive skin is a very common complaint globally It has several presentations that have led to different classification systems The Baumann Skin Typing System divides those with sensitive skin into four unique subtypes, which are discussed at length in other chapters Using this system can help provide insights into the causes of these various subgroups of sensitive skin, including the potential roles of gender and ethnicity pertaining to subtype, and should help lead to advances in the treatment of these subtypes
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REFERENCES
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the thickness of epidermis J Invest Dermatol 1962;39:295 Thomson ML Relative efficiency of pigment and horny layer thickness in protecting the skin of Europeans and Africans against solar ultraviolet radiation J Physiol 1955;127:236 Weigand DA, Haygood C, Gaylor JR Cell layers and density of Negro and Caucasian stratum corneum J Invest Dermatol 1974;62:563 Reinertson RP, Wheatley VR Studies on the chemical composition of human epidermal lipids J Invest Dermatol 1959;32:49 Weigand DA, Gaylor JR Irritant reaction in Negro and Caucasian skin South Med J 1974;67:548 Marshall EK, Lynch V, Smith HV Variation in susceptibility of the skin to dichlorethylsulphide J Pharmacol Exp Ther 1919;12:291 Weigand DA, Mershon GE The cutaneous irritant reaction to agent Ochlorobenzylidene malonitrile (CS) Quantitation and racial influence in human subjects Edgewood Arsenal Technical Report 4332 February, 1970 Kligman AM, Kwong T An improved rabbit ear model for assessing comedogenic substances Br J Dermatol 1979; 100:699 Morris WE, Kwan SC Use of the rabbit ear model in evaluating the comedogenic potential of cosmetic ingredients J Soc Cosmet Chem 1983;34:215 Mills OH, Kligman AM Human model for assessing comedogenic substances Arch Dermatol 1982;118:903 Mills OH, Berger RS Defining the susceptibility of acne prone and sensitive skin populations to extrinsic factors Dermatol Clin 1991;9:93 Frosch P, Kligman AM Method for appraising the sting capacity of topically applied substances J Soc Cosmet Chem 1977;28:197 Marriott M, Holmes J, Peters L, et al The complex problem of sensitive skin Contact Dermatitis 2005;53:93 Seidenari S, Francomano M, Mantovani L Baseline biophysical parameters in subjects with sensitive skin Contact Dermatitis 1998;38:311
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