Diagnosis, Immunity in VS .NET

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Diagnosis, Immunity
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cancer cells, and then return the cleansed blood back into circulation [Study suggestion: Picture the oil ltration system of your car How does it cleanse and purify the circulating oil How is this somewhat like the situation for the human bloodstream ] Figure 51 shows partly how the body achieves its blood- ltering functions There is a lymphatic circulation with lymphatic vessels that closely shadow the blood circulation and its blood vessels The tiniest vessels are called the capillaries (CAP-ih-lahr-eez) This is because they are extremely narrow and have the nature of (-ary) tiny hairs (capill) Therefore, the lymphatic capillaries shadow or run alongside the blood capillaries The blood pressure (BP), which pushes the blood through the blood capillaries, also pushes outward This causes a net ltration ( l-TRAY-shun) or process of ltering of materials out of the bloodstream When the ltrate (FIL-trayt) ltration product enters the nearby lymphatic capillaries, it then becomes the lymph (limpf) The lymph is named for its resemblance to clear spring water So, lymph is clear-looking and watery, rather than reddish (like
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Fig 51 Dirty blood in the blood capillaries becomes dirty lymph within the
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nearby lymphatic capillaries
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PART 2
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Cells and Body Defense
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the blood) However, when the lymph is rst formed by ltration of the blood, it is still quite dirty, because dirt, debris, bacteria, and cancer cells that were inside the bloodstream also get ltered into the lymph! Tracing the lymph ow in Figure 51, you can see that the tiny lymphatic capillaries eventually ow into much larger lymphatic veins, then lymphatic ducts Finally, the cleansed lymph returns back to the blood veins Okay, but what happens to clean this dirty lymph along the way you might now be asking yourself As you can see in Figure 52, it gets cleaned up by owing through a number of different lymphatic organs
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A brief look at the immune response
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Figure 52 shows the dirty lymph owing into lymph nodes (nohds) at one end, and clean lymph owing out, at the other In between, we get the operation of the immune response (Figure 53) Foreign bacteria, cancer cells, and various other body invaders found in dirty lymph all have their surfaces tagged by antigens
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Fig 52 The major lymphatic organs: Cleansers of dirty lymph
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Diagnosis, Immunity
Fig 53 A brief overview of the immune response
The word antigen (AN-tih-jen) means produced (-gen) against (anti-) An antigen is a foreign protein (PROH-teen) or chemical marker that is present on the outer membrane surrounding an invading cell (Figure 53 shows these invading cells as foreign bacteria) Several types of lymphocytes (LIMPF-oh-sights) literally clear spring water (lymph) cells (cyt) are present within the lymph nodes One type of lymphocyte acts as a scout, detecting the antigen (foreign protein marker) present on the invading bacterial
PART 2
Cells and Body Defense
cells It sends a stimulating message (indicated by the plus sign in Figure 53) to another type of lymphocyte This second type of lymphocyte then transforms itself into an entirely different type of cell This new cell type is called a plasma (PLAZ-muh) cell It is easily recognized under the compound microscope by the unique clock-face appearance of its nucleus (NOO-klee-us) (The nucleus is the small, rounded, kernel [nucle] present [-us] within most cells) The plasma cell is unique because it is the main source of our antibodies (ANtih-bah-dees) These antibodies are special types of proteins (Y-shaped bodies) that act against (anti-) foreign invaders Speci cally, the Y-shaped antibodies chemically attach and bind to the pointy antigens on the surfaces of the bacterial cells (This is somewhat like two oppositely shaped puzzle pieces tting together) The result is called an antigen-antibody reaction:
Following the antigen-antibody reaction (the combining of antibodies with antigens), the foreign bacteria cells undergo lysis (LIE-sis), a chemical explosion or breakdown (lys) This lysis ( process of breaking down ), of course, very effectively kills many thousands of the invading bacteria! But there is another part of the total immune response we haven t yet mentioned It is called phagocytosis (fay-go-sigh-TOH-sis) a process of (-osis) cell (cyt) eating ( phag) The bottom portion of Figure 53 shows a wandering macrophage, a large (macr) eater ( phag) that is present ( e) Such macrophages, as their name suggests, wander throughout the vessels and organs of the lymphatic system Whenever they encounter a foreign invader, they engulf or eat it
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