Disorders of Cells and Tissues in .NET

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Disorders of Cells and Tissues
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Fig 67 Normal A&P and the Great Pyramid of Structure-Function Order
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PART 2
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Cells and Body Defense
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Nucleus or Ribosomes (dark bodies composed of RNA plus ribose )
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Fig 68 Some of the organelles within a cell
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(dee-ox-ee-RYE-boh-new-klee-ik) acid Each DNA molecule, in turn, consists of many short sections called genes (JEANS) It is the genes that are our basic units of heredity Whether you have blue, green, or brown eyes, for instance, is largely determined by the particular sequence of genes found within the DNA molecules of your chromosomes You may have heard the recent news that scientists have unraveled the genome (JEE-nohm) What is meant by the genome is the group (-ome) of producers (gen) within a cell In layman s lingo, this means that the genome is the total collection of chromosomes and their genes, which act to produce many body proteins Note back in Figure 68 that there are a number of darkish-colored, rounded objects within the cell These include the nucleolus (new-KLEE-uh-lus) It is a little kernel (nucleol) that is present (-us) as a black dot in the center of the nucleus And not to be ignored are the numerus ribosomes (RYE-boh-sohms) The ribosomes are literally dark bodies (somes) containing the important sugar substance called ribose Both the nucleolus and ribosomes have in common the fact that they are largely composed of RNA These three letters are the abbreviation for ribonucleic (RYE-boh-new-klee-ik) acid RNA (ribonucleic acid) has a critical role to play as the helper for DNA during protein synthesis creation of the important proteins in the body Another sphere-shaped cell organelle is called the lysosome (LIE-soh-zohm) This word exactly translates to mean breakdown (lys) body (som) that is present (-e) The lysosomes are really tiny bags of digestive (die-JES-tiv)
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Disorders of Cells and Tissues
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enzymes (EN-zighms), surrounded and contained with a thin membrane Let s say that a particular cell, such as a leukocyte, carries out an extensive phagocytosis ( 5) of bacteria One or more lysosomes move toward the ingested bacteria and rupture Their digestive enzymes are released and chemically dissolve the bacterium The resulting nutrients (NOO-tree-unts) ones that (-ents) nourish (nutri) are then used by the cell for its metabolism By metabolism we mean a state of (-ism) change (metab) The breakdown of various nutrients provides the free energy required to carry out cell metabolism These involve the various body changes (such as cell division, protein synthesis, and movement) necessary for life Finally, we will consider a distinct organelle with a very unusual personality of its own: the mitochondrion (my-toh-KAHN-dree-un)! A careful look at Figure 69 makes known the underlying etymology (et-uh-MAHL-uh-jee) study of (-ology) the original meaning of a word (etym) The etymology (original LatinGreek meaning) of mitochondrion is presence of (-ion) a thread (mito) granule (chondr) The mitochondrion assumes two differing shapes In some cases it is long and slender, much like a thread (mito) In other instances it is rather rounded and oval, much like a granule (chondr) Observe that the internal anatomy of the two mitochondria (my-toh-KAHNdree-ah) pictured in Figure 69 includes thin crests or ridges called cristae (KRISS-tee) These cristae resemble the teeth of a comb
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Fig 69 The internal anatomy of a mitochondrion
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PART 2
Cells and Body Defense
Aerobic cell metabolism and ATP
The mitochondrion is frequently nicknamed the Powerhouse of the Cell The reason is that the mitochondrial (my-toh-KAHN-dree-al) cristae are the main sites for aerobic (air-OH-bik) metabolism within human cells By aerobic we mean pertaining to (-ic) something that lives (ob) in oxygen or air (aer) The mitochondria take in both oxygen and glucose (GLOO-kohs) from the surrounding cytoplasm (SIGH-toh-plazm) The cytoplasm is the uid matter (plasm) in the cell (cyt) (Review Figure 68) Glucose is the most important sugar or sweet molecule used for fuel within our body s cells Glucose is a ring-shaped molecule or little mass composed of six carbon (C) atoms and a number of oxygen (O) and hydrogen (H) atoms (View Figure 610) These C, O, and H atoms are all linked to another by means of chemical bonds The molecular (muh-LEK-you-ler) or pertaining to little mass formula of glucose is C6 H12 O6 , or C6 (H2 O)6 When written as C6 (H2 O)6 , the nature of glucose as a type of carbohydrate (kar-bohHIGH-drayt) molecule is revealed Speci cally, glucose is a carbon (carbo) and water (hydr) molecule a molecule whose formula can be written as an equal number of carbon atoms and water molecules (in this case, six of each) (The molecular formula for water, of course, is H2 O) Glucose is the key type of carbohydrate (carbon-water molecule) broken down for energy during metabolism Glucose is broken down within each mitochondrion under aerobic (oxygen-living) conditions, yielding a molecule called ATP as its end product And ATP, in turn, is the nal chemical broken down by cell metabolism that releases free energy to do body work The technical name for this metabolic process is glycolysis (gleye-KAHL-ih-sis) the breaking down (lys) of a glucose or sweet (glyc) carbohydrate molecule (Look over Figure 611) [Further study suggestion: Two of our related books, BIOLOGY DEMYSTIFIED and PHYSIOLOGY DEMYSTIFIED, include much more extensive discussion about the vital subject of aerobic metabolism and cell energy production using ATP] To summarize:
AEROBIC METABOLISM Uses O2, Glucose ATP MOLECULES PRODUCED (broken down by cells for energy)
(occurs within mitochondria)
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