PART 2 in .NET framework

Generating EAN-13 Supplement 5 in .NET framework PART 2

PART 2
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Cells and Body Defense
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(disease-related) terminology The answer is that both the hyper- (above normal or excessive) and hypo- (below normal or de cient) states are pretty tightly linked to the occurrence of morbidity (illness) and mortality (death) Thus, they are closely associated with the medical terminology describing illness and death To summarize:
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BIOLOGICAL DISORDER (ABNORMAL A&P) PARTIAL OR TOTAL FAILURE OF HOMEOSTASIS FOR ONE OR MORE PHYSIOLOGICAL PARAMETERS and/or A STATE OF MORBIDITY OR MORTALITY
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UNSTABLE, BROKEN PATTERNS OF BODY STRUCTURE
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Whenever we are talking about disease, injury, or death in future chapters, therefore, we will essentially be referring back to one or more levels of the Great Pyramid of Structure-Function Disorder Figure 614 features this Great Pyramid of abnormal anatomy and abnormal physiology for each of the nine levels of body organization Quite appropriately, these levels are given verbal levels of pathological (path-oh-LAHJ-ih-kal) anatomy for disordered body structures and pathophysiology (path-oh- z-ee-AHL-uh-jee) for disordered living body functions Once again, our helpful icon to symbolize such unhealthy body conditions is our poor Professor Joe but this time he is in a fallen and fractured state!
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CELLULAR PATHOLOGY AND TISSUE NECROSIS
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We have now thoroughly canvassed the entire Pyramid of Body Structure and Function, and we have considered it from two opposite viewpoints: (1) biological order, homeostasis, the normo- (normal) state, and clinical health at one end of the spectrum; versus (2) biological disorder, partial or total failures of homeostasis, the hyper- (excessive, above normal) and hypo- (de cient, below normal) states, and the occurrence of morbidity or mortality at the opposite end Zooming in on level V (cells and the Life-line), we are nally ready to discuss medical terminology at the cellular level In 1855, a German pathologist named Rudolf Virchow (FEER-koh) stated the principle of cellular pathology This principle says that the individual cell is the fundamental unit of pathology Dr Virchow closely examined slides of diseased tissues from hundreds of sick or dead patients In almost every case of whole-body disease he studied, some abnormality or disorder could be seen in the anatomy of the cells from the
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Disorders of Cells and Tissues
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Fig 614 The Great Pyramid of Structure-Function Disorder
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patient! Hence, he concluded that a systemic (sis-TEM-ik) or whole body system disease that can kill you, such as cancer, usually begins from a single point one or more diseased cells The principle of cellular pathology can be considered part of a larger theory This larger concept is called the localistic (low-kal-IS-tik) theory of disease causation The basic idea is that disease usually begins at a particular local level in some relatively small area of the body, such as one or more cells It then spreads from cells to tissues (families of related cells) Then, from the tissue level (VI) on the Great Body Pyramid, it just keeps spreading biological disorder and morbidity to higher and higher levels SUMMARY OF LOCALISTIC THEORY OF DISEASE CAUSATION: Cell Tissue Organ Organ system abnormality abnormality disease disease
(Disease starting at a local area)
Systemic (whole-body) disease
A similar situation exists for necrosis (neh-KROH-sis) This term indicates an abnormal condition of (-osis) death (necr) Let s say, for example, that
PART 2
Cells and Body Defense
a few cardiac muscle cells in the heart wall are deprived of oxygen during a so-called heart attack The cardiac muscle cells, because they are starved for O2 and highly aerobic, can no longer produce ATP energy Thus, they become necrotic (neh-KRAHT-ik) that is, they die off A similar cellular necrosis occurs in neighboring areas of the heart wall Eventually, the cellular necrosis of individual cardiac muscle cells becomes a tissue necrosis of the cardiac muscle in the heart wall The heart pumps less and less blood, until the heart organ itself becomes necrotic The heart fails to pump enough blood to the rest of the body The whole circulatory system fails, and the entire body dies
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