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Consult Summary Table 62 for a quick review of some important words and word parts
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Summary Table 62 Words and Word Parts
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Write in the exact meaning (literal English translation) for up to 10 key terms selected from the preceding block of text After you are done, check your word meanings with the correct answers, which are given at the end of this chapter Key Terms broblast histology Pre xes (none) (none) Roots br ber Suf xes Exact Meanings
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-blast former 1 2
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hist -ology web or tissue study of theli nipples
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epithelial
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epi- upon
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-al 3 pertaining to -ia condition of 4
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hypothermia
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hypotherm de cient; heat below normal hypertherm excessive; heat above normal (none) necr death
hyperthermia
-ia 5 condition of
necrosis
-osis abnormal condition of
Disorders of Cells and Tissues
Medical Case History: Terminal Lung Cancer in a Chronic Smoker A Bad Dream of Hyperplasia
Gwendolyn S, age 58, was a chronic smoker She had smoked 3 1/2 packs per day for more than 20 years! Inhaling deeply, she frequently exclaimed, Well, ya gotta die of somethin ! About 6 years ago, Ms S was diagnosed with a case of chronic bronchitis (brahn-KEYE-tis) an in ammation of (-itis) the bronchi (BRAHN-keye) The bronchi are the main air tubes branching off the trachea (TRAY-kee-ah) or windpipe (See Figure 615, A) Recently, she has complained of nearly constant and very intense coughing spells that even keep her awake at night! The patient came to see her family doctor after sharp, stabbing, localized chest pains on the left side scared her A radiographic exam of the chest cavity was employed to obtain a bronchogram (BRAHN-koh-gram) This is an x-ray record (-gram) of the bronchi (bronch) A large oval neoplasm (NEE-oh-plazm) or new (neo-) growth (plasm) was visualized in the interior of the left primary bronchus (View Figure 615, B) This new growth was certainly the result of an abnormal tumorigenesis (TOO-mor-ih-JEN-eh-sis) the production of (-genesis) a swelling or enlargement (tumor) It involved an abnormal hyperplasia (highper-PLAY-zhuh) This term indicates an excessive (hyper-) amount of tissue formation (plas) Neoplasms created by hyperplasia may be either benign (bee-NINE) kind or malignant (mah-LIG-nant) wicked Malignant neoplasms are considered wicked because they often undergo metastasis (muh-TAS-tuh-sis) This is literally a process of (-is) changing over (meta-) to another place (stas) During metastasis, abnormal cells spread, or metastasize (muh-TAS-tuhsize), from their original location toward various other parts of the body Since malignant neoplasms do not function normally, their spreading or metastasis all over the body can often be fatal! In summary:
Hyperplasia NORMAL TISSUE or Malignant neoplasms Metastasize (Spread)
Hyperplasia Benign neoplasms Do not metastasize
In the case of Gwendolyn S, a small sample of the neoplasm was removed by biopsy Microscopic examination by a pathologist revealed that the epithelial cells in the neoplasm had strange nuclei that were very pleomorphic (plee-oh-MORF-ik) occurring in more than one (pleo-) shape (morph)
PART 2
Cells and Body Defense
Neoplasm
Cross-section through left bronchus
Fig 615 The bronchi in normal and cancerous states (A) Overview showing right and
left bronchi branching off from the trachea (B) Interior view of left bronchus via bronchogram, showing neoplasm
However, most of these cells still had a generally at and scaly or squamous (SKWAH-mus) form Such highly abnormal cells con rmed the initial suspicion that the lesion was malignant A diagnosis of squamous cell carcinoma (kar-sin-OH-muh) of the lung was made A carcinoma in general is a crab (carcin) tumor (-oma) Carcinoma or cancer is de ned as a malignant neoplasm of epithelial tissue It is symbolized by the crab, which can pinch between its claws and cause lots of body damage! Most unfortunately, metastasis from the primary site within the left primary bronchus had already progressed into the ribs and the left lung The patient was put onto a high dosage of anticancer (an-tih-CAN-sir) chemotherapy and tissue-destroying radiation Only time will tell if she can survive!
Probe of case history
(A) There was a hyperplasia of new, highly abnormal epithelial tissue within the lung tumor What if there had been a hypoplasia instead Would the mass of tissue become larger, or smaller, than its original size How would you translate hypoplasia into its common English equivalent (B) Assume that the diagnosis had been a benign squamous neoplasm In this situation, what would you not
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