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Our Body Senses
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well as an exocrine portion (the pancreatic acini and pancreatic duct) Let us put all of this knowledge together into a simple word equation for the entire glandular system The result is:
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THE = ENDOCRINE + GLANDS GLANDULAR SYSTEM (internal secretion
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of hormones directly into the bloodstream)
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EXOCRINE GLANDS
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MIXED GLANDS
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(external secretion of useful products into ducts)
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(contain both endocrine and exocrine components)
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Endocrine diseases
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Using our basic overview of the glands, we can discuss a few representative examples of endocrine diseases (The important and complex subject of the endocrine glands is covered in much greater depth in ANATOMY DEMYSTIFIED and PHYSIOLOGY DEMYSTIFIED) Let us talk now about giants and dwarfs! And when we do such an intriguing thing, we are not talking about the normosecretion (nor-moh-see-KREEshun) normal secretion of certain hormones Normosecretion, like the normotension and normothermia mentioned in earlier chapters, is generally associated with biological order and clinical health [Anticipation probe: Based on your prior reading, what do you anticipate are the general categories of secretion associated with morbidity ] In general, endocrine diseases are of two broad kinds: (1) diseases of hormone hypersecretion (high-per-see-KREE-shun), which is an above normal or excessive secretion; or (2) diseases of hormone hyposecretion (high-pohsee-KREE-shun), which is a below normal or de cient amount of secretion Bringing everything together yields: HORMONE NORMOSECRETION while HORMONE HYPERSECRETION = Biological disorder and endocrine diseases of hormone excess = Biological disorder and endocrine diseases of hormone de ciency = Biological order and clinical health of associated body parameters
and HORMONE HYPOSECRETION
Gland and Skin Disorders
Giants and dwarfs
We could go through dozens of different endocrine diseases But any particular disease that we chose to study would either be a disease of hormone excess or one of hormone de ciency Keeping this simple statement in mind should help you demystify this complex eld for yourself ! Perhaps the most clear (and physically startling!) contrasts between endocrine diseases having these two exactly opposite hormone conditions are provided by the pituitary body This oval body includes the anterior pituitary (pih-TOOih-tair-ee) gland, which sits toward the front (anteri) Among the many hormones that the anterior pituitary secretes, growth hormone (GH) provides us with a ne example Growth hormone (GH) is secreted into the bloodstream by the anterior pituitary gland and then circulates throughout the body Quite unusual among the hormones, its targets are almost every cell within the human organism! Growth hormone stimulates such very basic cellular functions as protein synthesis, growth, and cell division As you might expect, GH levels are usually highest in the bloodstream during the early years of life, when our bodies are still growing and adding billions of new cells Its rate of secretion then tapers off as the body matures over time What happens if a young child s secretion of GH is abnormally low, Noble Hippocrates In this case, we have a hyposecretion of GH and a depressed level of protein synthesis, body growth, and cell division The endocrine disease that may result is called pituitary dwar sm (DWARF-izm) There is a severe retardation of growth during childhood, so that the adult is unusually short But in a pituitary dwarf (unlike some other kinds of dwarfs), the body limbs and parts are only slightly out of their normal proportion (See Figure 106 [A] right) What about the exactly opposite problem of a young child with an abnormally high secretion of GH If the GH hypersecretion is chronic, so that the excess (hyper-) amount lasts for several years during early childhood, then pituitary gigantism (jeye-GANT-izm) may result Gigantism is literally a condition of (-ism) being a giant (gigant) (Study Figure 106 [B] left) In such cases of gigantism that are the result of hypersecretion of GH, the affected person has an extremely tall stature, but the body limbs usually remain in their normal proportions What if the person is already an adult and they have a large hypersecretion of GH In this situation, the person can t get any taller, of course, because the growth plates in their long bones have already fully ossi ed (AHS-ihfeyed) turned to bone (ossi) So instead of the bones getting longer, they get thicker and heavier! The of cial medical term for this problem is acromegaly (AK-roh-meg-ah-lee) (Examine part (C) near the top of Figure 106) There is
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