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SPECIFIC DISORDERS 11 Font J, Ramos-Casals M, de la Red G, et al Pure sensory neuropathy in primary Sjogren s syndrome Long term prospective followup and review of the literature J Rheumatol 2003;30(7):1552 1557 12 Rosenbaum R Neuromuscular complications of connective tissue diseases Muscle Nerve 2001;24(2):154 169 13 Chai J, Herrmann DN, Stanton M, Barbano RL, Logigian EL Painful small- ber neuropathy in Sjogren syndrome Neurology 2005;65(6):925 927 14 Lopate G, Pestronk A, Al-Lozi M, et al Peripheral neuropathy in an outpatient cohort of patients with Sjogren s syndrome Muscle Nerve 2006;33(5):672 676 15 Kovacs L, Paprika D, Takacs R, et al Cardiovascular autonomic dysfunction in primary Sjogren s syndrome Rheumatology 2004;43(1):95 99 16 Goto H, Matsuo H, Fukudome T, Shibuya N, Ohnishi A, Nakamura H Chronic autonomic neuropathy in a patient with primary Sjogren s syndrome J Neurol Neurosurg Psychiatry 2000;69(1):135 17 Urban PP, Keilmann A, Teichmann EM Hopf HC Sensory neuropathy of the trigeminal, glossopharyngeal, and vagal nerves in Sjogren s syndrome J Neurol Sci 2001;186(1 2): 59 63 18 Asahina M, Kuwabuara S, Asahina M, Nakajima M, Hattori T D-penicillamine treatment for chronic sensory ataxia neuropathy associated with Sjogren s syndrome Neurology 1998;51:141 1453 19 Hankey GJ, Gubbay SS Peripheral neuropathy associated with sicca syndrome J Neurol Neurosurg Psychiatry 1987;50:1085 20 Laloux P, Brucher JM, Guerit JM, et al Subacute sensory neuronopathy associated with Sjogren s sicca syndrome J Neurol 1988;235:352 354 21 Auger RG, Windebank AJ, Lucchinetti CF, Chalk CH Role of the blink re ex in the evaluation of sensory neuronopathy Neurology 1999;53:407 408 22 Auger RG The role of the masseter re ex in the assessment of subacute sensory neuropathy Muscle Nerve 1998;21:800 801 23 Kizawa M, Mori K, Iijima M, Koike H, Hattori N, Sobue G Intravenous immunoglobulin treatment in painful sensory neuropathy without sensory ataxia associated with Sjogren s syndrome J Neurol Neurosurg Psychiatry 2006;77(8):967 969 24 Chen WH, Yeh JH, Chiu HC Plasmapheresis in the treatment of ataxic sensory neuropathy associated with Sjogren s syndrome Eur Neurol 2001;45(4):270 274 25 Chamberlain MA, Bruckner FE Rheumatoid neuropathy: Clinical and electrophysiologic features Ann Rheum Dis 1970;29:609 616 26 Peyronnard J-M, Charron L, Beaudet F, et al Vasculitic neuropathy in rheumatoid disease and Sjogren s syndrome Neurology 1982;32:839 845 27 Scott DGI, Bacon PA, Tribe CR Systemic rheumatoid vasculitis: A clinical and laboratory study of 50 cases Medicine 1981;60:288 297 28 Weller RO, Bruckner FE, Chamberlain MA Rheumatoid neuropathy: A histological and electrophysiological study J Neurol Neurosurg Psychiatry 1970;33:592 604 29 Hughes RAC, Cameron JS, Hass SM, et al Multiple mononeuropathy as an initial presentation of systemic
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Type IV amyloidosis is caused by mutations in the gelsolin gene on chromosome159 161 Gelsolon is an actinbinding protein found in plasma, leukocytes, and other cell types The resultant mutations and amino acid substitutions lead to a charge change on the protein, which may render the molecule resistant to proteases
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As discussed, neuropathies may complicate many different systemic disorders It is important to distinguish neuropathies that may be directly related to the underlying disorder, caused by treatment (toxic neuropathy), or just be coincidental occurrence as management may differ according to the etiology Thus, as discussed in 1 it is always important to take a detailed medical history and examination to assess for an underlying systemic disorder that may be associated with the neuropathy
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1 Gemignani F, Marbini A, Pavesi G, et al Peripheral neuropathy associated with primary Sjogren s syndrome J Neurol Neurosurg Psychiatry 1994;57:983 986 2 Grant IA, Hunder GG, Homburger HA, Dyck PJ Peripheral neuropathy associated with sicca complex Neurology 1997;48:855 862 3 Grif n JW, Cornblath DR, Alexander E, et al Ataxic sensory neuropathy and dorsal root ganglionitis associated with Sjogren s syndrome Ann Neurol 1990;27:304 315 4 Kennett RP, Harding AE Peripheral neuropathy associated with sicca syndrome J Neurol Neurosurg Psychiatry 1986;49:90 92 5 Malinow K, Yannakakis GD, Glusman SM, et al Subacute sensory neuronopathy secondary to dorsal root ganglionitis in primary Sjogren s syndrome Ann Neurol 1986;20:535 537 6 Mellgren S, Conn DL, Steven JC, et al Peripheral neuropathy in primary Sjogren s syndrome Neurology 1989;39:390 394 7 Gorson KC, Ropper AH Positive salivary gland biopsy, Sjogren syndrome, and neuropathy: Clinical implications Muscle Nerve 2003;28(5):553 560 8 Ramos-Casals M, Anaya JM, Garcia-Carrasco M, et al Cutaneous vasculitis in primary Sjogren syndrome: Classi cation and clinical signi cance of 52 patients Medicine 2004;83(2):96 106 9 Mori K, Iijima M, Sugiura M, et al Sjogren s syndrome associated painful sensory neuropathy without sensory ataxia J Neurol Neurosurg Psychiatry 2003;74(9):1320 1322 10 Mori K, Iijima M, Koike H, et al The wide spectrum of clinical manifestations in Sjogren s syndrome-associated neuropathy Brain 2005;128:2518 2534
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