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Tamarin: Principles of Genetics, Seventh Edition
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IV. Quantitative and Evolutionary Genetics
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19. Population Genetics: The Hardy Weinberg Equilibrium and Mating Systems
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Population Genetics: The Hardy-Weinberg Equilibrium and Mating Systems
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4. The frequency of children homozygous for the recessive allele for cystic brosis is about one in twenty- ve hundred. What is the percentage of heterozygotes in the population 5. PTC tasting is dominant in human beings. a. Should most human populations be heading toward a 3:1 ratio of tasters to nontasters Explain. b. Confronted with a population sample of human beings of unknown origin, would you expect more or less than half the sample to be tasters 6. Graph the relationship of the proportions of genotype (AA, Aa, aa) as allelic frequencies change. 7. A particular recessive disorder is present in one in ten thousand individuals. If the population is in Hardy-Weinberg equilibrium, what are the frequencies of the two alleles 8. What allelic frequency will generate twice as many recessive homozygotes as heterozygotes 9. Assume brown eye color is the result of a dominant allele at one locus. Attack or defend mathematically the following statement: With time, the frequency of brown-eyed individuals will increase, until about three out of four individuals are brown-eyed. 10. A particular human population has ve hundred MM individuals, three hundred MN, and seven hundred NN. Calculate the allelic frequencies, and determine whether the population is in Hardy-Weinberg equilibrium. 11. Assume random mating occurs among the individuals of the population described in problem 10. What will be the frequency of each type of individual in the next generation 12. On a small island, 235 mating individuals are all truebreeding for brown eyes. An epidemic eliminates all the population except ten young women, two young men, and four older (postmenopausal) women. A boatload of foreigners arrives; the foreign population consists of six heterozygous brown-eyed females, four homozygous brown-eyed males, and ten blue-eyed males. Assuming that one locus controls eye color, that mating is random with respect to eye color, and that each male and female capable of breeding does so, calculate the genotypic frequencies of their offspring. 13. In a given population, only the I A and I B alleles are present in the ABO system; there are no individuals with type O blood or with i alleles. If two hundred people have type A blood, seventy- ve have type AB blood, and twenty- ve have type B blood, what are the allelic frequencies in this population
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14. The following data are ABO phenotypes from a population sample of one hundred persons. Determine the frequencies of the three alleles: type A, seven; type B, seventy-two; type AB, twelve; type O, nine. What do you have to assume Is the population in Hardy-Weinberg proportions 15. How quickly and in what manner is Hardy-Weinberg equilibrium achieved under the following initial conditions (assuming a diploid, sexually reproducing population) a. One locus, ve alleles b. Two unlinked loci, two alleles each 16. A sample of fruit ies was testcrossed to determine the allelic arrangements of two linked loci in the gametes of that generation. With the following data, can you determine whether linkage equilibrium holds Gametic arrangements are AB, fty-eight; ab, eight; Ab, twelve; and aB, twenty-two. 17. In a large, randomly mating human population, the frequencies of the I A, I B, and i alleles are 0.7, 0.2, and 0.1, respectively. Calculate the expected frequencies for each blood type. 18. In a human population of one hundred people, seventeen have type A blood, seventeen have type B, two have type AB, and sixty-four have type O. If this population is in equilibrium, what are the allelic frequencies
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19. Under what circumstances is inbreeding deleterious 20. What is the inbreeding coef cient of I in the following pedigree Assume that the inbreeding coef cients of other members of the pedigree are zero unless other information tells you differently.
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