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16. The following data are from Mendel s original experiments. Suggest a hypothesis for each set and test this hypothesis with the chi-square test. Do you reach different conclusions with different levels of signi cance a. Self-fertilization of round-seeded hybrids produced 5,474 round seeds and 1,850 wrinkled ones. b. One particular plant from a yielded 45 round seeds and 12 wrinkled ones. c. Of the 565 plants raised from F2 round-seeded plants, 372, when self-fertilized, gave both round and wrinkled seeds in a 3:1 proportion, whereas 193 yielded only round seeds. d. A violet- owered, long-stemmed plant was crossed with a white- owered, short-stemmed plant, producing the following offspring: 47 violet, long-stemmed plants 40 white, long-stemmed plants 38 violet, short-stemmed plants 41 white, short-stemmed plants 17. Mendel self-fertilized pea plants with round and yellow peas. In the next generation he recovered the following numbers of peas: 315 round and yellow peas 108 round and green peas 101 wrinkled and yellow peas 32 wrinkled and green peas What is your hypothesis about the genetic control of the phenotype Do the data support this hypothesis 18. Two agouti mice are crossed, and over a period of a year they produce 48 offspring with the following phenotypes: 28 agouti mice 7 black mice 13 albino mice
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(See also USE OF RULES) 11. A normal man (A) whose grandfather had galactosemia and a normal woman (B) whose mother was galactosemic want to produce a child. What is the probability that their rst child will be galactosemic 12. A city had nine hundred deaths during the year, and of these, three hundred were from cancer and two hundred from heart disease. What is the probability that the next death will be from a. cancer b. either cancer or heart disease 13. A plant that has the genotype AA bb cc DD EE is mated with one that is aa BB CC dd ee. F1 individuals are selfed. What is the chance of getting an F2 plant whose genotype exactly matches the genotype of one of the parents
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Tamarin: Principles of Genetics, Seventh Edition
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II. Mendelism and the Chromosomal Theory
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4. Probability and Statistics
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The McGraw Hill Companies, 2001
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What is your hypothesis about the genetic control of coat color in these mice Do the data support that hypothesis 19. Two curly-winged ies, when mated, produce sixtyone curly and thirty- ve straight-winged progeny. Use a chi-square test to determine whether these numbers t a 3:1 ratio. 20. A short-winged, dark-bodied y is crossed with a long-winged, tan-bodied y. All the F1 progeny are
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long-winged and tan-bodied. F1 ies are crossed among themselves to yield 84 long-winged, tanbodied ies; 27 long-winged dark-bodied ies; 35 short-winged, tan-bodied ies; and 14 short-winged, dark-bodied ies. a. What ratio do you expect in the progeny b. Use the chi-square test to evaluate your hypothesis. Is the observed ratio within the expected range
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C R I T I C A L
T H I N K I N G
Q U E S T I O N S
1. A friend shows you three closed boxes, one of which contains a prize, and asks you to choose one. Your friend then opens one of the two remaining boxes, a box she knows is empty. At that point, she gives you the opportunity to change your choice to the last remaining box. Should you
2. If all couples wanted at least one child of each sex, approximately what would the average family size be
Suggested Readings for chapter 4 are on page B-2.
Tamarin: Principles of Genetics, Seventh Edition
II. Mendelism and the Chromosomal Theory
5. Sex Determination, Sex Linkage, and Pedigree Analysis
The McGraw Hill Companies, 2001
SEX DETERMINATION, SEX LINKAGE, AND PEDIGREE ANALYSIS
STUDY OBJECTIVES
1. To analyze the causes of sex determination in various organisms 83 2. To understand methods of dosage compensation 90 3. To analyze the inheritance patterns of traits that loci on the sex chromosomes control 95 4. To use pedigrees to infer inheritance patterns 97
STUDY OUTLINE
Sex Determination 83 Patterns 83 Sex Chromosomes 83 Sex Determination in Flowering Plants 87 Dosage Compensation 90 Proof of the Lyon Hypothesis 90 Dosage Compensation for Drosophila 94 Sex Linkage 95 X Linkage in Drosophila 95 Nonreciprocity 96 Sex-Limited and Sex-In uenced Traits 96 Pedigree Analysis 97 Penetrance and Expressivity 97 Family Tree 98 Dominant Inheritance 99 Recessive Inheritance 99 Sex-Linked Inheritance 100 Summary 103 Solved Problems 103 Exercises and Problems 104 Critical Thinking Questions 108 Box 5.1 Why Sex and Why Y 88 Box 5.2 Electrophoresis 92
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