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D E C R E A S I N G T H E B U R D E N O N Y O U R D E T O X I F I C AT I O N S Y S T E M S
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Adequate sleep provides needed rest, which in turn brings about more positive feelings. Moderate daily exercise helps provide deeper sleep at night and a more relaxed feeling throughout the day. If necessary, investigate the many natural options available for the treatment of anxiety, such as the herbs kava kava and Saint-John swort. SAMe (s-adenosylmethionine) is also an option for people who are depressed. Herbal supplements should be used only when needed and/or as prescribed by a licensed physician. Although a certain amount of stress can help us to cope during an emergency, it is not a normal state of being and must be dealt with if we are to maintain our health. In this chapter we have surveyed the main sources of destructive chemicals in our daily lives both environmental and those made in our bodies. I have shared some suggestions we offer at AMC for keeping these toxins at bay. The more successful we are in doing this, the better the chances for our detoxification systems to operate as nature intended, provided of course that we nourish them with the right foods and supplements. We will discuss both these factors at length in the coming chapters.
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C H A P T E R
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T H R E E
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Superfoods That Detoxify
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t the time of my postdoctoral fellowship at the McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, 1968 1971, my research was focused on investigating the process by which environmental agents cause cancer. We knew that certain combustion by-products called polycyclic aromatic hydrocarbons, which are found in cigarette smoke, charcoalgrilled and burned meats, burning fuel, forest fires, and chimney smoke, played a role in cancer formation by damaging our genetic material. We observed this in laboratory experiments we performed using a group of mice, each of which possessed a similar genetic characteristic of an increased susceptibility to cancer. Every time we exposed the mice to these compounds, they would, without exception, get cancer; if they were not exposed, they would not. But we did not understand how this happened, as polycyclic aromatic hydrocarbon molecules are inert, meaning they should not be active in the body. Eventually we discovered that when the body tries to rid itself of clearly carcinogenic compounds by attempting to change them from lipid or oil-soluble to water-soluble, it falters and malfunctions. A natural attempt to heal itself instead results in the oxygenation of these compounds into a form (epoxides) that can easily bind with our genetic material and do extensive damage. If this damage is not repaired, genetic mutations can result and lead to cancer.
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THE DETOX REVOLUTION
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We studied ways to interfere with this binding process. That was when I began to work with flavonoids, a class of simple plant compounds in fruits and vegetables, which my colleagues and I believed might have just such ability. We were absolutely amazed to discover through our research just how effective flavonoids and later other nutritionally related compounds and specific vitamins were in counteracting the effects of combustion by-products and preventing cancer.
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W HAT A RE F LAVONOIDS
Flavonoids are ubiquitous in plants. There are at least two thousand different naturally occurring flavonoids. The flavonoids consist mainly of flavonols, flavones, and their glycosides (sugar attached), proanthocyanidins, anthocyanins, and catechins. Among the most common are the flavonols quercetin and rutin, which are present in tea, coffee, grains, and a variety of fruits and vegetables. Proanthocyanidins, or condensed tannins, are polyflavonoid in nature and are widely distributed in foods such as apples, grapes, berries, plums, and grains. Anthocyanins are responsible to a major degree for the various brilliant colors of flower petals and fruits. The catechins are also widely distributed in plants but are in the highest concentrations in tea leaves. Because of their common presence in plants, flavonoids are an integral and important part of our diet.
As you might imagine, flavonoid-rich foods started to look pretty significant to us in preventing cancer by specifically supporting the processes of detoxification. I was so impressed with our findings that I began to include more flavonoid foods in our family s diet. We even started supplementing with vitamins, although at that time we really didn t understand that vitamins such as the powerful detoxifyers, C and E for instance, should be taken together because they support each other s functions. As the years went by, nutrition science evolved, giving us more information about not only what kinds of foods and supplements are important, but also in what combinations they provide the optimum health-protective benefits. Some people have greater genetic susceptibility to the adverse effects of environmental toxins than others. For them, it is extraordinarily
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