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A superior multivitamin and mineral formulation should contain more than the RDA. For example, amounts higher than the RDA for the B-complex vitamins in the presence of coenzyme Q10 and carnitine are necessary to provide enough energy for people living in a fast-paced and stressful society.
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Pyridoxine, pyridoxal, and pyridoxamine are the vitamins collectively known as vitamin B6. Vitamin B6 is important in the metabolism of proteins and amino acids, helps regulate blood glucose levels, is necessary for the manufacture of hemoglobin, is important in normalizing nervous system function, and plays a key role in enabling the brain to transmit nerve impulses. Vitamin B6 promotes healthy skin, teeth, gums, and blood vessels. It also helps the body in the utilization of carbohydrates and essential fatty acids for energy, promotes the production of antibodies, and provides support for the overall healthy function of the immune system. Vitamin B6 is one of the most critical of all the vitamins; it participates as a coenzyme in more than sixty enzymatic reactions. Vitamin B12 (cyanocobalamin) is a very important vitamin that contains the trace mineral cobalt. Known as vitamin B12, it works together with folic acid in reactions that are critical to the process of cell division and in making DNA and RNA. It is critical for bone growth, the integrity of the central nervous system, and normal blood formation. Vitamin B12 deficiencies, especially as a result of poor absorption, are related to certain anemias, especially pernicious anemia. Vitamin B12 promotes utilization of proteins, fats, and carbohydrates. In addition to its significance in cell division and the making of DNA and RNA, as with other B vitamins, folic acid is important in red blood cell maturation and other metabolic processes. It is essential for the functions of vitamins A, D, E, and K and it aids in the digestion of proteins. Folic acid is necessary for normal neural tube formation during development and it is especially needed during pregnancy and childhood development. Folic acid, together with vitamins B12 and B6, is important in the process of methylation. Biotin is a water-soluble vitamin essential for the metabolism of carbohydrates. It is a coenzyme in the synthesis of fatty acids and amino acids and it stimulates the production of proteins. Biotin has been found to enhance insulin sensitivity and increase glucose utilization in the liver. Choline is not a vitamin, but it is related in function to the vitamin B-complex. Proper fat metabolism in the liver depends on it. A deficiency can lead to liver cancer. Choline is essential for making acetylcholine and important components of cell membranes such as lecithin (phosphatidylcholine) and an important molecule called sphingomyelin. Choline is also needed as a methyl donor in some methylation reactions, especially in the liver. Although choline can be made in the body, it is nevertheless considered to be an essential micronutrient. Choline and myo-inositol, the other B-complex-related nonvitamin, are important components of cell membranes and help in the absorption
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and digestion of fats including the export of fats from the liver. Supplementing with choline and myo-inositol helps to prevent liver disorders, diabetes, and depression.
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Vitamin C is a very potent antioxidant. It prevents nitrosamine formation in the stomach; prevents the activation of PAHs to cancer-causing agents; and decreases radiation-induced toxicity, mutations, and cancer. Vitamin C works synergistically with several other vitamins and minerals as well as other antioxidants to lower cancer and cardiovascular disorder rates and to increase the protective effect of the immune system. It is critical for producing and maintaining collagen, healing wounds, aiding tooth and bone formation, and producing hormones that regulate basal metabolic rate and body temperature. Vitamin C also aids in the metabolism of amino acids and calcium. It promotes stamina and contributes to the reduction of infection, colds, fatigue, stress, and allergies. Dr. Linus Pauling, a two-time Nobel Laureate, spent years studying vitamin C s beneficial effects. Vitamin C s effectiveness is enhanced when combined with certain other nutrients. In citrus fruits, vitamin C is kept in a reduced (antioxidant) state by various flavonoids. Without them, vitamin C would be unable to do its job of neutralizing free radicals. Once vitamin C finds its way to our cells, ascorbic acid reductase helps to keep it in a reduced state. Lipoic acid and dihydrolipoate help vitamin C (and vitamin E) to destroy many different types of free radicals. Vitamin C helps to keep vitamin E in a reduced and active (antioxidant) state so it can destroy free radicals in cellular membranes as well.
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