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Beyond Basics: Breakthrough Supplements for Detoxification
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eople have practiced detoxification throughout the ages. In India, they fasted to cleanse the body and purify the spirit. In the rainforest, natives boiled herbs into detoxifying teas. Scandinavians had the sauna to encourage the release of impurities. In every culture throughout the world, since the beginning of ancient medicine, healers used a variety of methods to cleanse toxins from the body. What our ancestors did to encourage detoxification was based on intuition, experimentation, and observation. Today, hard science gives us our understanding of detoxification and the ways we can truly achieve it. While no doubt some of the traditional ways may have validity, this chapter is about the natural compounds that research shows to offer reliable results. And we have the technological advances to be able to isolate them into convenient supplements, something our ancestors could only dream about and probably did. Many supplements are available to promote health and longevity and prevent disease through the processes of detoxification. My focus here will be on compounds for supplementation that are supported by
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scientific research and have been found to have no known side effects or toxicity. I ll break them down into three categories: 1. those that enhance xenobiotic Phase I and Phase II detoxification and in most cases, also have antioxidizing activity 2. the powerful antioxidants 3. the important compounds that enhance methylation All of the supplements covered here have been found to help prevent cancer, cardiovascular diseases, neurological degeneration, inflammatory diseases, and diabetes. In addition, these important breakthrough compounds have been found to enhance the body s immune system. Supplements for Phase I and Phase II Detoxification
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silymarin green tea catechin polyphenols (80%) ellagic acid apigenin isothiocyanates and dithiolethiones allyl sulfides carnosol and ursolic acid curcumin chlorophyllin D-glucarate
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flavonoid flavonoid flavonoid flavonoid sulfur compound organosulfide terpenoid curcuminoids chlorophyll glucarate
100 250 mg 100 250 mg 20 50 mg 20 50 mg 200 500 mg 200 500 mg 50 100 mg 200 500 mg 200 500 mg 400 600 mg
Q UERCETIN AND RUTIN
Since quercetin and rutin are the most common flavonoids with health benefits (for xenobiotic detoxification) and are generally consumed in reasonable amounts, they need not be taken as a supplement.
B E Y O N D B A S I C S : B R E A K T H R O U G H S U P P L E M E N T S F O R D E T O X I F I C AT I O N
Supplements for Phase I and Phase II Detoxification
Silymarin
Silymarin is a group of flavonoids or flavonolignans from the seeds of milk thistle, a plant related to artichokes and daisies. An extract of milk thistle seeds contains 80 percent silymarin with silibinin, silidiamin, and silicristin being the active ingredients. Of these, silibinin is the most active and the one considered responsible for the health benefits attributed to silymarin, especially when it comes to liver protection and enhancing the detoxification of many dangerous toxins such as those from snakebites and mushroom poisoning. Extract of milk thistle has been used medicinally for almost two thousand years. Hundreds of scientific research studies have confirmed the remarkable ability of silymarin to protect the liver from all kinds of toxic and carcinogenic agents.
S ILYMARIN P ROTECTS THE L IVER
Hepatitis B and C viral infections have been shown to be responsive to silymarin. This flavonoid has been used in Germany for several decades to treat both viral and alcoholic hepatitis and cirrhosis.
Dr. K. Flofa at the Oregon Health Sciences University found that silymarin not only protects the liver cells against toxic damage but also helps to stimulate the liver to regenerate. In a double-blind controlled study, silymarin was found to significantly reduce the mortality of patients with liver cirrhosis. In another double-blind controlled study, silymarin was shown to decrease serum enzymes SGPT (serum glutamic pyruvate transaminase) and SGOT (serum glutamic oxalacetic transaminase), which are associated with liver damage. Many recent studies have shown that silymarin prevents cancers of the liver, skin, stomach, colon, lung, breast, and prostate. With regard to skin cancer, Dr. Mukhtar and his associates at Case Western University found that silymarin provides very effective protection against both ultraviolet light and chemical carcinogenesis. Silymarin protects against the development of cancer by increasing the detoxification activity of Phase II enzymes including glutathione-Stransferase (GST) and quinone reductase and conversely by inhibiting
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