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Ellagic Acid
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Ellagic acid, found in a variety of fruits, nuts, and vegetables including blackberries, raspberries, strawberries, cranberries, walnuts, and pecans is a relatively stable flavonoid or polyphenol that is very helpful in overall detoxification. Ellagic acid acts as a detoxifying agent in protecting against many different kinds of cancer and other diseases. It works by binding to reactive carcinogens, either produced by our cells or from external sources, and inactivating them before they can infiltrate DNA and cause mutations. Because of this effect, ellagic acid is a potent antimutagen and anticarcinogen. In addition, ellagic acid increases the activity of Phase II detoxification enzymes including GST and quinone reductase, and it has known antioxidizing properties. Dr. Conney and associates at Rutgers University and the National Cancer Institute and Dr. Mukhtar and associates at Case Western University found ellagic acid to be a potent inhibitor of skin cancer caused by some of the strongest reactive intermediates of carcinogenic polycyclic aromatic hydrocarbons (PAHs) that we know about.
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Dr. Stoner and coworkers at Ohio State University Cancer Center also found that ellagic acid prevented the induction of both lung and esophageal cancer induced by other classes of carcinogens. Ellagic acid has also been found to be effective in counteracting liver cancer brought on by a cancer-causing aromatic amine agent. In clinical studies conducted on women with a genetic risk of cervical cancer at the Medical University of South Carolina, ellagic acid was shown to decrease cancer risk. In cervical cancer cell studies in culture, ellagic acid induced cell death (apoptosis), which may be the way ellagic acid kills cancer cells. Similar results were found using prostate, breast, pancreas, esophageal, skin, and colon cancer cells. In other studies, ellagic acid promoted wound healing and reduced liver fibrosis. It provided protection against chromosome damage, DNA damage, and lipid peroxidation induced by radiation. These protective effects may be related to its antioxidizing activity.
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Apigenin
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Apigenin is a flavonoid found in parsley, artichokes, basil, celery, apples, onions, and other plants. It appears to counteract the induction of tumors by its effect on Phase I and Phase II detoxification, by increasing glutathione levels and by its antioxidizing activity. In the past several years, there have been many published reports on the protective effects of apigenin on the induction of cancer, especially skin cancer. Doctors Pelling and Birt, while conducting research at the Eppley Cancer Research Center, found that apigenin was a potent inhibitor of ultraviolet light induced skin cancer.
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Unpublished studies have shown apigenin to be protective against cancers induced by chemical carcinogens.
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In a study that compared twenty-one different flavonoids, apigenin was shown to be the most effective inhibitor of the growth of human breast cancer cells. Like tamoxifen, apigenin binds to the estrogen receptors and thus prevents the overstimulation of breast cancer cells by estrogens. In addition, apigenin was also shown to inhibit the growth of human leukemia cells, thyroid cancer cells, and colorectal cancer cells. Its effects of stimulating differentiation of cancer cells and inhibiting the
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epidermal growth factor signal transduction pathway may be related to its ability to inhibit the growth of cancer cells. In addition, apigenin was found to be a strong inhibitor of tyrosine kinases, which are key enzymes in the growth of cancer cells. Furthermore, apigenin, like several other flavonoids, is a potent inhibitor of the growth of blood vessels (angiogenesis), which cancer cells need in order to grow and invade surrounding areas of the body. Apigenin was also found to inhibit inflammation. This appears to be related to both its antioxidizing effect and its ability to inhibit an enzyme called cox-2 (cyclooxygenase-2), which is critical not only in inflammation but also for many cancer cells to grow.
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