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SAMe (s-adenosylmethionine) TMG (trimethylglycine)
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50 200 mg 200 500 mg
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THE DETOX REVOLUTION
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Compounds for Preventing Breast and Prostate Cancer
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There are additional specific substances besides the previously described supplements that help prevent breast and prostate cancer because of their ability to regulate the sex hormones. These substances can be taken by all adult men and women who want to decrease their risk of hormone-related cancers. Conjugated linolenic acid (CLA), isoflavones, indole-3-carbinol, and calcium D-glucarate are very helpful in supplying additional protection against breast cancer. These compounds help to prevent excess breast cell proliferation and prevent excess amounts of estrogens and metabolites, which can lead to breast cancer. Dr. Henry Thompson at the AMC Cancer Research Center has shown CLA to be a potent inhibitor of morphological and biochemical markers related to breast cancer. In addition, Dr. IP and coworkers at the Roswell Park Memorial Cancer Center found that CLA inhibited the induction of breast cancer. In these studies, CLA appears to inhibit breast cell proliferation and angiogenesis after the carcinogen was given. Isoflavones mimic weak estrogen and interact with estrogen receptors such as tamoxifen, helping to prevent overstimulation of breast tissue. Indole-3-carbinol causes the major estrogen, estradiol, to convert into harmless metabolites including 2-hydroxy as opposed to 4-hydroxy and 16-hydroxy, which have been related to breast cancer in some studies. Calcium D-glucarate helps to detoxify excess estrogens and cholesterol, a precursor of estradiol. Overall, these compounds lead to an effective regulation of estrogens that prevents them from contributing to the formation of breast cancer. In conjunction with a healthy diet, exercise, stress control, and proper supplementation for basic health and to support detoxification, these compounds round out an effective and rational approach to breast cancer prevention. Supplements for Breast Cancer Prevention
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CLA (70%) soybean isoflavones indole-3-carbinol calcium D-glucarate
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250 500 mg 100 300 mg 100 300 mg 200 500 mg
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B E Y O N D B A S I C S : B R E A K T H R O U G H S U P P L E M E N T S F O R D E T O X I F I C AT I O N
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Supplements for Prostate Cancer Prevention
COMPOUNDS THREE TIMES/DAY
CLA (70%) saw palmetto extract soybean isoflavones zinc D-glucarate
250 500 mg 200 600 mg 100 300 mg 200 600 mg
CLA, saw palmetto extract, isoflavones, and zinc D-glucarate are very helpful in supplying additional protection against prostate cancer. The strategy for prostate cancer prevention is similar to that for breast cancer. Here, both androgens and estrogens must be regulated to prevent excess prostate cell proliferation. A significant number of prostate cancers appear to be related to the overproduction of androgens, especially dihydrotestosterone (DHT). Key to keeping both androgens and estrogens in check is to maintain healthy cholesterol levels. This is because cholesterol gives rise to testosterone, the major androgen, which in turn converts to estradiol. CLA prevents prostate cancer by inhibiting cell proliferation and angiogenesis. Saw palmetto extract inhibits the formation of DHT, inhibits cox-2 enzyme, and prevents benign prostate hypertrophy (BPH). Soybean isoflavones have many beneficial effects on inhibiting the induction of prostate cancer, including the ability to regulate androgens and estrogens. Zinc D-glucarate helps to detoxify cholesterol, androgens, and estrogens. These compounds in combination with a good diet, proper exercise, healthy mental state, and my protocol for supplementation (with a particular emphasis on selenium, vitamin E especially gamma tocopherol and vitamin D3) is a very rational and effective strategy for preventing prostate cancer.
CHOLESTEROL IS A PRECURSOR TO ALL THE STEROID HORMONES
Cholesterol
Testosterone Estradiol
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C H A P T E R
S E V E N
Key Supplements for Chronic Disease Prevention
his chapter is for those who are interested in looking beyond supplements for cancer-related detoxification to supplements that deal specifically with other chronic diseases. It includes lists of the most important supplements for prevention of cardiovascular disorders, especially those related to cholesterol management; inflammatory diseases; immune disorders; bacterial and viral infection; obesity and diabetes; neurological degeneration; and aging. The supplements will reduce your risk of these chronic diseases whether you are in a high-risk category or not. As always, when embarking on a program of supplementation, first inform your physician. (If your doctor isn t interested in nutrition, find one who is. You ll be better off.)
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