THE DETOX REVOLUTION in .NET framework

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THE DETOX REVOLUTION
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Although the liver is the main organ for dealing with toxic bodily conditions, it is by no means the only one. The body s line of defense against external threats is shared among the three major portals through which harmful agents gain entry into our tissues. The first portal is the respiratory system where life-supporting oxygen enters the body, is converted to energy for the cells, and then exits in the form of carbon dioxide, a waste product. The second portal is the digestive system. This system processes food we ve eaten, then absorbs it into the circulatory system to be used as fuel and to provide building blocks for tissues and nutrients and other chemical components for critical bodily processes and reactions. The digestive system also determines whether ingested material is useless or dangerous to the body, and, if so, breaks it down and eliminates it through the intestines or absorbs it into the circulatory system to be eliminated via the liver. The third portal is the skin, which is the body s largest organ. The skin provides a barrier against external environmental pollutants.
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D ETOXIFICATION O CCURS T HROUGHOUT THE B ODY
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Enzymes essential for the detoxification of environmental chemicals and metals, as well as chemicals produced by our bodies such as steroid hormones, are not just found in the liver, where the bulk of the cleanup process takes place. They are also found in oral and nasal passages, the respiratory and digestive systems, the skin, and most organs and tissues of the body.
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The Body s Two Major Detoxification Systems
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Humans in fact, all mammals have two major systems for eliminating harmful substances from the body: xenobiotic detoxification and antioxidant detoxification. It is important to understand both systems because, for good health, each must function at an extremely high level.
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The Xenobiotic Detoxification System
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The first system, known as xenobiotic detoxification, disarms healththreatening chemicals and metals from food, water, and air.
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D E T O X I F I C AT I O N : T H E K E Y T O W E L L N E S S
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It also neutralizes dangerous substances produced within the body. During this process of detoxification, which consists of many different types of complex enzymatic reactions, the body metabolizes or changes these substances to a less dangerous form (Phase I) and converts them if necessary to a water-soluble state (Phase II), something the body requires before it can effectively eliminate them.
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T OXINS M IX WITH O IL OR WATER
Toxic agents, whether environmental air and water pollutants, food additives, or internally produced steroidal hormones such as estrogens, are either water based or oil based. Scientists have a very good idea of how the processes of detoxification work. Cytochrome P-450 is an important class of Phase I enzymes. These enzymes add oxygen to various chemicals such as steroid hormones produced by the ovaries, testes, and adrenal glands, and polycyclic aromatic hydrocarbons, a combustion byproduct, to make them less toxic. Then, because these toxins are highly fat soluble, Phase II has to bind them to other molecules (a process known as conjugation) to make them sufficiently water soluble for elimination through urination. Other toxic agents go through a similar process but are eliminated through the feces. Toxins are made water soluble through enzymatic processes involving glucuronide, glutathione, and sulfate, which is used in the enzymatic process to conjugate the steroid hormones in our illustration. Glutathione is employed in modifying particularly reactive toxins. But the majority of toxins, approximately 80 percent, are made water soluble by enzymatic processes involving glucuronide or glucuronic acid. These processes are called glucuronidation. Carcinogens such as polycyclic aromatic hydrocarbons, nitrosamines, heterocyclic amines, aromatic amines, and many other toxins are conjugated by this process. Glucuronidation is the key Phase II detoxification process. It takes place in every tissue of our bodies. In some cases, Phase I enzymes can actually increase the cancer-causing activity of environmental compounds such as polycyclic aromatic hydrocarbons if there is insufficient Phase II detoxification. Other enzymes involved in the metabolism of carcinogens, such as peroxides and transferase, can also lead to greater carcinogenic activity under certain conditions.
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