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The McGraw Hill Companies, 2001
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component of tness A particular aspect in the life cycle of an organism upon which natural selection acts. composite transposon A transposon constructed of two IS elements anking a control region that frequently contains host genes. concordance The amount of phenotypic similarity between individuals. condensin A protein complex including SMC (structural maintenance of chromosomes) proteins needed for the condensation of interphase chromosomes to mitotic chromosomes. conditional-lethal mutant A mutant that is lethal under one condition but not lethal under another. con dence limits A statistical term for a pair of numbers that predicts the range of values within which a particular parameter lies. conjugation A process whereby two cells come in contact and exchange genetic material. In prokaryotes, the transfer is a one-way process. consanguineous Meaning between blood relatives ; usually refers to inbreeding or incestuous matings. consensus sequence A sequence of the common nucleotides found in many different DNA or RNA samples of homologous regions (e.g., promoters). conservative replication A postulated mode of DNA replication in which an intact double helix acts as a template for a new double helix; known to be incorrect. conserved sequence A sequence found in many different DNA or RNA samples (e.g., promoters) that is invariant in the sample. constitutive heterochromatin Heterochromatin that surrounds the centromere. See satellite DNA. constitutive mutant A mutant whose transcription is no longer under regulatory control. contigs Genomic libraries of overlapping, contiguous clones that cover complete regions of a chromosome. continuous replication In DNA, uninterrupted replication in the 5 to 3 direction using a 3 to 5 template. continuous variation Variation measured on a continuum rather than in discrete units or categories (e.g., height in human beings). corepressor The metabolite that when bound to the repressor (of a repressible operon) forms a functional unit that can bind to its operator and block transcription. correlation coef cient A statistic that gives a measure of how closely two variables are related. cosmid A hybrid plasmid that contains cos sites at each end. Cos sites are recognized during head lling of lambda phages. Cosmids are useful for cloning segments of foreign DNA up to 50 kb.
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cotransduction The simultaneous transduction of two or more genes. coupling Allelic arrangement in which mutants are on the same chromosome and wild-type alleles are on the homologue. covariance A statistical value measuring the simultaneous deviations of x and y variables from their means. CpG islands Stretches of CG repeats (in which CpG indicates sequential bases on the same strand of DNA, rather than a C-G base pair).These repeats, found in imprinting centers, are important in regulation. crisscross pattern of inheritance The phenotypic pattern of inheritance controlled by X-linked recessive alleles. critical chi-square A chi-square value for a given degree of freedom and probability level, to which we can compare an experimental chi-square. crossbreed To facilitate fertilization between separate individuals. cross-fertilization See crossbreed. crossing over A process in which homologous chromosomes exchange parts by a breakage-and-reunion process. crossovers See chiasmata. crossover suppression The apparent lack of crossing over within an inversion loop in heterozygotes. Usually due to mortality of zygotes carrying defective crossover chromosomes rather than to actual suppression. C-value paradox Structural and junk DNA create large eukaryotic genomes and large differences in DNA content between eukaryotic species. cyclic AMP A form of AMP (adenosine monophosphate) used frequently as a second messenger in eukaryotic hormone nets and in catabolite repression in prokaryotes. cyclin Family of proteins involved in cell cycle control. cyclin-dependent kinase (CDK) Family of kinases (phosphorylating enzymes) that, when combined with cyclin, are active in controlling checkpoints in the cell cycle. cyclosome See anaphase-promoting complex (APC). cytogenetics The study of cells from the perspective of genetics. In practice, the study of changes in the gross structure and number of chromosomes in cells. cytokinesis The division of the cytoplasm of a cell into two daughter cells. See karyokinesis. cytoplasmic inheritance Extrachromosomal inheritance controlled by nonnuclear genomes. cytosine See pyrimidines. cytotoxic T lymphocytes T cells responsible for attacking host cells that have been infected with an invading bacterium or virus.
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dauermodi cation The persistence for several generations of an environmentally induced trait. degenerate code A code in which several code words have the same meaning. The genetic code is degenerate because many different codons may specify the same amino acid. degrees of freedom An estimate of the number of independent categories in a particular statistical test or experiment. deletion chromosome A chromosome with part deleted. deme A locally interbreeding population. denatured Loss of natural con guration (of a molecule) through heat or other treatment. Denatured DNA is single-stranded. denominator elements Genes on the autosomes of Drosophila that regulate the sex switch (sxl ) to the off condition (maleness). Refers to the denominator of the X/A genic balance equation. density-gradient centrifugation A method of separating molecular entities by their differential sedimentation in a centrifugal gradient. depauperate fauna A fauna, especially common on islands, lacking many species found in similar habitats. derepressed The condition of an operon that is transcribing because repressor control has been lifted. deterministic Referring to events that have no random or probabilistic aspects but proceed in a xed, predictable fashion. development The process of orderly change an individual goes through in the formation of structure. diakinesis The nal stage of prophase I of meiosis. dicentric chromosome A chromosome with two centromeres. dictyotene A prolonged diplonema of primary oocytes that can last many years. dideoxy method A method of DNA sequencing that uses chain-terminating (dideoxy) nucleotides. dihybrid An organism heterozygous at two loci. dimerization The chemical union of two similar molecules. diploid Having each chromosome in two copies per nucleus or cell. diplonema (diplotene stage) The stage of prophase of meiosis I in which chromatids appear to repel each other. directed mutation A form of mutation that appears to respond to the needs of the cell but may, in fact, be due to the cell s hypermutable state under duress. directional selection A type of selection that removes individuals from one end of a phenotypic distribution and thus causes a shift in the distribution. disassortative mating The mating of two individuals with dissimilar phenotypes.
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