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Tamarin: Principles of Genetics, Seventh Edition
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II. Mendelism and the Chromosomal Theory
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5. Sex Determination, Sex Linkage, and Pedigree Analysis
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The McGraw Hill Companies, 2001
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Sex Determination, Sex Linkage, and Pedigree Analysis
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blind. This couple has a color-blind daughter with a normal complement of chromosomes. Is in delity suspected Explain. 18. A white-eyed male y is mated with a pink-eyed female. All the F1 offspring have wild-type red eyes. F1 individuals are mated among themselves to yield:
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Females red-eyed pink-eyed 450 155 Males red-eyed white-eyed pink-eyed 231 301 70
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F2: 27 red-eyed, tan-bodied 24 white-eyed, tan-bodied 9 red-eyed, dark-bodied 7 white-eyed, dark-bodied (No differences between males and females in the F2 generation.)
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Provide a genetic explanation for the results. 19. In Drosophila, white eye is an X-linked recessive trait, and ebony body is an autosomal recessive trait. A homozygous white-eyed female is crossed with a homozygous ebony male. a. What phenotypic ratio do you expect in the F1 generation b. What phenotypic ratio do you expect in the F2 generation c. Suppose the initial cross was reversed: ebony female white-eyed male. What phenotypic ratio would you expect in the F2 generation 20. In Drosophila, abnormal eyes can result from mutations in many different genes. A true-breeding wildtype male is mated with three different females, each with abnormal eyes. The results of these crosses are as follows:
male abnormal-1 male abnormal-2 male abnormal-3 Females all normal 1/2 normal, 1/2 abnormal all abnormal Males all normal 1/2 normal, 1/2 abnormal all abnormal
23. What is the difference between penetrance and expressivity 24. What are the possible modes of inheritance in pedigrees a c in gure 4 What modes of inheritance are not possible for a given pedigree
Explain the results by determining the mode of inheritance for each abnormal trait. 21. A black and orange female cat is crossed with a black male, and the progeny are as follows: females: two black, three orange and black males: two black, two orange Explain the results. 22. Based on the following Drosophila crosses, explain the genetic basis for each trait and determine the genotypes of all individuals: white-eyed, dark-bodied female red-eyed, tanbodied male F1: females are all red-eyed, tan-bodied; males are all white-eyed, tan-bodied
(c) Figure 4 (b)
Three pedigrees showing different modes of inheritance.
Tamarin: Principles of Genetics, Seventh Edition
II. Mendelism and the Chromosomal Theory
5. Sex Determination, Sex Linkage, and Pedigree Analysis
The McGraw Hill Companies, 2001
Exercises and Problems
25. In pedigrees a d in gure 5, which show the inheritance of rare human traits, including twin production, determine which modes of inheritance are most probable, possible, or impossible. 26. Hairy ears, a human trait expressed as excessive hair on the rims of ears in men, shows reduced penetrance (less than 100% penetrant). Mechanisms proposed include Y linkage, autosomal dominance, and
autosomal recessiveness. Construct a pedigree consistent with each of these mechanisms. 27. Construct pedigrees for traits that could not be a. autosomal recessive. b. autosomal dominant. c. sex-linked recessive. d. sex-linked dominant.
8 1 2
1 (a)
2 1 2
5 3 4 (b)
4 1 2
Pedigrees of rare human traits, including twin production (a).
Tamarin: Principles of Genetics, Seventh Edition
II. Mendelism and the Chromosomal Theory
5. Sex Determination, Sex Linkage, and Pedigree Analysis
The McGraw Hill Companies, 2001
Five
Sex Determination, Sex Linkage, and Pedigree Analysis
28. Determine the possible modes of inheritance for each trait in pedigrees a c in gure 6.
6 (b)
4 (a) 5
Varying modes of inheritance.
C R I T I C A L
T H I N K I N G
Q U E S T I O N S
1. What effects do null alleles, alleles that produce no protein product, have in electrophoretic systems How could you tell if a null allele were present 2. In 1918, the Bolsheviks killed Tsar Nicholas II of Russia and his family ( g. 5.22). However, the remains of one
daughter, Princess Anastasia, were never recovered. At one point, a woman appeared who claimed to be Anastasia. How could you validate her claim genetically
Suggested Readings for chapter 5 are on page B-2.
Tamarin: Principles of Genetics, Seventh Edition
II. Mendelism and the Chromosomal Theory
6. Linkage and Mapping in Eukaryotes
The McGraw Hill Companies, 2001
LINKAGE AND MAPPING IN EUKARYOTES
STUDY OBJECTIVES
1. To learn about analytical techniques for locating the relative positions of genes on chromosomes in diploid eukaryotic organisms 110 2. To learn about analytical techniques for locating the relative positions of genes on chromosomes in ascomycete fungi 122 3. To learn about analytical techniques for locating the relative positions of genes on human chromosomes 132
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